Longevity & AgingSGLT2 Diabetes Drugs Linked to 39% Lower Dementia Risk in People With Mood Disorders
A new study published in JAMA Network Open found that SGLT2 inhibitors — a class of diabetes drugs — were associated with a significantly lower risk of developing dementia in older adults with major depression, bipolar disorder, or schizophrenia. Using data from over 112,000 veterans aged 65 and older, researchers found that those who used SGLT2 inhibitors were 39% less likely to develop dementia compared to non-users. The drugs were also linked to fewer psychiatric emergency department visits. People with serious psychiatric conditions face a higher baseline dementia risk and are rarely included in prevention research, making this finding especially significant for a historically underserved population.
