Autoimmune disorders, rheumatoid arthritis, systemic inflammation, and immune dysregulation
330 articles
A blinded head-to-head comparison finds a fully automated single-copy RNA assay detects residual HIV in over 57% of suppressed patients, versus ≤40% for manual methods.
GZMK+CD8+ T cells promote chronic inflammation and aging-related disease—a newly recognized immune threat beyond cytotoxicity.
New research reveals efgartigimod reshapes B-cell populations in myasthenia gravis, inducing regulatory plasma cells linked to clinical improvement.
A completed French trial investigated whether rogue antibodies targeting ghrelin and alpha-MSH disrupt appetite regulation in eating disorder patients.
Phase 1 trial examines whether vesatolimod can safely stimulate immune response in HIV controllers during treatment interruption.
A Phase 4 trial compares two antiretroviral strategies in treatment-naive HIV patients with dangerously low CD4 counts below 100.
A meta-analysis of 19,000 children finds JIA patients are significantly more likely to develop thyroid autoimmunity, with clear screening targets identified.
A comprehensive JAMA review clarifies first-line treatments for acute and chronic low back pain, reshaping clinical practice.
Researchers tested whether eosinophil β1 integrin activation in blood could track disease activity, potentially sparing patients repeat invasive procedures.
GlaxoSmithKline tests a novel NS5B inhibitor across four dose groups in chronic HCV patients, evaluating safety and short-term antiviral activity.
A major Lancet review reveals 27 million women suffer postpartum haemorrhage annually, costing $10.4B and claiming 43,000 lives — with most deaths preventable.
A Phase 1 pilot trial explores whether the IL-12/23 blocker ustekinumab is safe and can reduce systemic inflammation in Sjögren's patients.
