Aging biology, lifespan extension, hallmarks of aging, and healthspan optimization
4,119 articles
Excess dietary phosphate raises FGF23, which crosses into the brain and triggers sympathetic overactivation and high blood pressure via FGFR4.
A comprehensive review of hyperphosphatemia covers phosphate physiology, hormonal regulation, and clinical consequences for aging and kidney health.
New review reveals how declining Klotho levels drive insulin resistance and type 2 diabetes, positioning this anti-aging protein as a potential biomarker.
A UK Biobank study of 38,000+ adults finds that high fitness delays the onset of multiple chronic diseases by over a year.
A meta-analysis of 38 studies reveals older heart failure patients have dramatically lower peak oxygen uptake than controls, declining further with each decade.
Cardiorespiratory fitness independently predicts morbidity and mortality. Danish review explains why VO₂max may be your most important health metric.
A landmark review maps the dose-response curve between cardiorespiratory fitness and mortality, revealing J-shaped risks at exercise extremes.
Celastrol outperforms leading senolytics by targeting the Hsc70-Bim protein complex, clearing zombie cells and reducing organ fibrosis in mice and flies.
A pilot study finds structured moderate exercise doesn't trigger aortic events in dissection survivors, challenging decades of medical caution.
Key cancer findings: renaming low-risk prostate cancer could save 2,400 lives yearly, tamoxifen cuts breast cancer risk, and rural screening access worsens.
New research links lacunar stroke to enlarged brain blood vessels, not artery plaque — explaining why aspirin often fails these patients.
An 8-hour feeding window extended median lifespan in male mice by 12%, though caloric restriction may explain part of the benefit.
