Longevity & Aging
How Misfolded Proteins Get Flagged for Destruction Inside Your Cells
New research reveals how defective newly-made proteins expose hidden molecular tags, triggering rapid cellular cleanup.
Research Paper
Jul 5, 2026 0
Research Topic
Longevity & Aging
Aging biology, lifespan extension, hallmarks of aging, and healthspan optimization
4,123 articles
Longevity & Aging
Natural Compounds May Fine-Tune a Key Aging Enzyme Better Than Drugs
A new review reveals how natural compounds could modulate EZH2 — a critical epigenetic enzyme — to slow aging without the risks of strong drug inhibition.
Review
Jul 5, 2026 0
Longevity & Aging
Blood Rejuvenation and Epigenetic Reset May Work Better Together Against Aging
A new review argues that systemic blood recalibration and partial cellular reprogramming target different axes of aging and should be combined.
Review
Jul 5, 2026 0
Longevity & Aging
Can What You Eat Actually Clear Senescent Cells? A Systematic Review Weighs In
A systematic review of 27 human trials finds calorie restriction best modulates senescence markers, but direct evidence remains elusive.
Review
Jul 5, 2026 0
Longevity & Aging
High Phosphate Diets Drive Hypertension by Hijacking Brain Growth Factor Signaling
Excess dietary phosphate raises FGF23, which crosses into the brain and triggers sympathetic overactivation and high blood pressure via FGFR4.
Research Paper
Jul 4, 2026 0
Longevity & Aging
Hyperphosphatemia Explained: How Excess Phosphate Disrupts Your Body
A comprehensive review of hyperphosphatemia covers phosphate physiology, hormonal regulation, and clinical consequences for aging and kidney health.
Research Paper
Jul 4, 2026 0
Longevity & Aging
Klotho Protein Emerges as Key Link Between Aging and Insulin Resistance
New review reveals how declining Klotho levels drive insulin resistance and type 2 diabetes, positioning this anti-aging protein as a potential biomarker.
Research Paper
Jul 4, 2026 0
Longevity & Aging
High Cardiorespiratory Fitness Cuts Multimorbidity Risk by 21% Over 15 Years
A UK Biobank study of 38,000+ adults finds that high fitness delays the onset of multiple chronic diseases by over a year.
Research Paper
Jul 4, 2026 0
Longevity & Aging
Heart Failure Slashes Exercise Capacity in Older Adults and Worsens With Age
A meta-analysis of 38 studies reveals older heart failure patients have dramatically lower peak oxygen uptake than controls, declining further with each decade.
Research Paper
Jul 4, 2026 0
Longevity & Aging
VO₂max Is Your Longevity Engine — Here's Why Fitness Predicts How Long You Live
Cardiorespiratory fitness independently predicts morbidity and mortality. Danish review explains why VO₂max may be your most important health metric.
Research Paper
Jul 4, 2026 0
Longevity & Aging
VO2 Max Is the Strongest Longevity Predictor — Here's the Optimal Exercise Dose
A landmark review maps the dose-response curve between cardiorespiratory fitness and mortality, revealing J-shaped risks at exercise extremes.
Research Paper
Jul 4, 2026 0
Longevity & Aging
Plant Compound Celastrol Clears Senescent Cells and Extends Lifespan in Animal Models
Celastrol outperforms leading senolytics by targeting the Hsc70-Bim protein complex, clearing zombie cells and reducing organ fibrosis in mice and flies.
Research Paper
Jul 4, 2026 0
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