Aging biology, lifespan extension, hallmarks of aging, and healthspan optimization
2910 articles
New research reveals cholecystectomy reshapes gut bacteria and bile acids, suppressing FXR signaling and accelerating colorectal tumor growth.
New research shows taurine suppresses p53-driven senescence in pancreatic β-cells, offering a potential strategy to preserve insulin secretion with age.
A bile acid found in blood predicts and treats obesity-induced endothelial dysfunction through a newly discovered FXR-ATF4 metabolic axis.
New research shows that stripping DNA methylation from cancer cells—without causing DNA damage—drives them into irreversible cellular senescence.
A novel SQSTM1-mediated selective autophagy pathway degrades p16 and p21, reducing cellular senescence in degenerative mitral valve disease.
New research finds DSAD brains carry twice the iron of controls, triggering lipid peroxidation and cell death pathways linked to ferroptosis.
A 2025 review reveals how two sulfur-based amino acids act as master regulators of cellular redox balance and age-related decline.
Tiny lab-engineered peptides mimicking the brain's own antioxidant enzyme show protective effects across a striking range of age-related diseases.
New research shows mitochondrial H₂O₂ isn't just a toxic byproduct—it actively orchestrates neural stem cell proliferation and cortical layering.
A new study shows ferroptosis drives cellular senescence, and blocking it with ferrostatin-1 extends lifespan and healthspan in worms and aging mice.
GH drops sharply as we age, mimicking deficiency states — yet boosting it in older adults shows mixed results and real risks.
A supervised resistance exercise program improved physical performance and reduced frailty biomarkers in adults aged 100+, a first-of-its-kind trial.
