Aging biology, lifespan extension, hallmarks of aging, and healthspan optimization
1460 articles
CRISPR-GPT uses large language models to guide researchers through complex gene editing workflows, successfully demonstrating automated knockout and activation experiments.
Breakthrough study shows CRISPR activation can restore brain function in genetic disorders by boosting remaining healthy gene copies.
Scientists identify RBPJ protein as key brake on regulatory T cells, opening path to more effective autoimmune treatments.
Comprehensive review reveals how CRISPR innovations are revolutionizing genome editing with enhanced precision and safety for therapeutic applications.
Genome-wide CRISPR screening reveals three key genes that, when knocked out, dramatically enhance NK cell therapy against cancer.
Researchers identify TIGR-Tas systems that could expand genome editing capabilities beyond CRISPR technology.
New study shows physical training reduces senescent cells in skeletal muscle and improves metabolic function in both lean and obese individuals.
Scientists develop mGL392, a precision senolytic that targets aging cells using lipofuscin binding while minimizing systemic toxicity.
New review reveals senolytic therapies can both help and harm cardiovascular health, challenging clinical translation.
Comprehensive review reveals how cellular senescence drives lung aging and disease, highlighting therapeutic potential of senolytics and senomorphics.
Researchers discover a high-plasticity cell state that enables cancer progression and therapy resistance, offering new therapeutic targets.
Researchers identify specific inflammatory kidney cells that could be targeted with existing drugs to slow chronic kidney disease progression.
