Aging biology, lifespan extension, hallmarks of aging, and healthspan optimization
1509 articles
FDA-approved heart drug sotatercept demonstrates wide-ranging effects on blood vessels, muscle health, and red blood cell production.
Growth factor GDF11 prevents cartilage breakdown and inflammation in osteoarthritis by targeting mitochondrial dysfunction and NLRP3 inflammasome.
New research reveals how β-hydroxybutyrate enhances mitochondrial function by promoting cellular cleanup through vesicle formation.
Review reveals how Klotho protein protects against periodontitis, oral cancer, and other mouth diseases through multiple cellular pathways.
Review reveals how αKlotho protein controls mineral metabolism and offers therapeutic potential for age-related diseases.
Scientists develop method to map three types of brain molecules simultaneously, revealing metabolic changes in neurodegeneration.
First controlled study shows therapeutic plasma exchange safely reduces biological age markers across multiple molecular pathways.
Study reveals how the metabolite alpha-ketoglutarate prevents arterial hardening by modulating DNA methylation and inflammation.
Scientists discover how TCA cycle enzyme OGDH directs intestinal cell differentiation, offering new therapeutic targets for inflammatory bowel disease.
Research identifies how PDHA1 succinylation creates metabolic changes that help bile duct cancer evade immune detection.
Researchers discover apigenin, found in fruits and vegetables, blocks harmful senescent cell activity and improves aging outcomes in mice.
New research reveals how stress hormones trigger cancer cells to send harmful signals to nerves, accelerating tumor growth.
