Research Topic

Longevity & Aging

Aging biology, lifespan extension, hallmarks of aging, and healthspan optimization

1549 articles

Four Endogenous Metabolites Show Promise for Extending Human Lifespan
Longevity & Aging

Four Endogenous Metabolites Show Promise for Extending Human Lifespan

Review identifies taurine, betaine, α-ketoglutarate, and other naturally-produced compounds that may delay aging through multiple cellular pathways.

Research Paper
Mar 29, 2026 1
Five Types of Home Oxygen Therapy Support Chronic Disease Management
Longevity & Aging

Five Types of Home Oxygen Therapy Support Chronic Disease Management

Comprehensive review outlines evidence-based oxygen delivery methods for patients with chronic pulmonary and cardiac conditions.

Research Paper
Mar 29, 2026 2
Brain Implants Restore Movement and Speech in Paralyzed Patients Through Neural Interfaces
Longevity & Aging

Brain Implants Restore Movement and Speech in Paralyzed Patients Through Neural Interfaces

New neuroprosthetic devices enable paralyzed patients to regain grasping, walking, and fluid communication through brain-computer interfaces.

Research Paper
Mar 29, 2026 1
Epigenetic Clocks Could Revolutionize Personalized Anti-Aging Skin Treatments
Longevity & Aging

Epigenetic Clocks Could Revolutionize Personalized Anti-Aging Skin Treatments

New research shows biological age markers can guide personalized aesthetic treatments that target aging at the molecular level.

Research Paper
Mar 29, 2026 1
Rare PEComa Tumors Show Promise for Targeted mTOR Inhibitor Therapy
Longevity & Aging

Rare PEComa Tumors Show Promise for Targeted mTOR Inhibitor Therapy

Comprehensive review reveals new molecular subtypes and treatment options for perivascular epithelioid cell tumors affecting multiple organs.

Research Paper
Mar 29, 2026 2
Aging Immune System Drives Cancer Growth and Therapy Resistance
Longevity & Aging

Aging Immune System Drives Cancer Growth and Therapy Resistance

Comprehensive review reveals how immunosenescence creates tumor-promoting environments and reduces treatment effectiveness in elderly cancer patients.

Research Paper
Mar 29, 2026 1
Rapamycin Shows Promise for Longevity But Safety Concerns Remain for Healthy Adults
Longevity & Aging

Rapamycin Shows Promise for Longevity But Safety Concerns Remain for Healthy Adults

Comprehensive review examines rapamycin's anti-aging potential, revealing mixed results and significant safety considerations for off-label use.

Research Paper
Mar 29, 2026 1
Senolytics Show Promise for Osteoporosis But Clinical Results Lag Behind Lab Studies
Longevity & Aging

Senolytics Show Promise for Osteoporosis But Clinical Results Lag Behind Lab Studies

New review examines senolytic drugs that target aging cells in bone tissue, revealing gaps between promising animal studies and human trials.

Research Paper
Mar 29, 2026 1
Cellular Senescence Shows Dual Role in Cancer: Tumor Suppressor and Promoter
Longevity & Aging

Cellular Senescence Shows Dual Role in Cancer: Tumor Suppressor and Promoter

New review reveals how senescent cells both prevent and fuel cancer, opening doors to precision therapies targeting aging pathways.

Research Paper
Mar 29, 2026 1
Senolytics and Senomorphics Show Promise for Targeting Aging at the Cellular Level
Longevity & Aging

Senolytics and Senomorphics Show Promise for Targeting Aging at the Cellular Level

Comprehensive review reveals how drugs that eliminate or modify senescent cells could revolutionize anti-aging medicine.

Research Paper
Mar 29, 2026 4
AI Agents Discover Anti-Aging Drugs by Mining 2 Million Molecular Profiles
Longevity & Aging

AI Agents Discover Anti-Aging Drugs by Mining 2 Million Molecular Profiles

Autonomous AI system reanalyzed millions of studies to find 500+ interventions that reduce biological age, validating ouabain in mice.

Research Paper
Mar 29, 2026 1
ACBP Protein Drives Aging by Blocking Autophagy, Antibody Treatment Reverses Damage
Longevity & Aging

ACBP Protein Drives Aging by Blocking Autophagy, Antibody Treatment Reverses Damage

Centenarians have 3x higher ACBP levels. Blocking this aging protein with antibodies prevents organ damage and cellular senescence.

Research Paper
Mar 29, 2026 1
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