Research Topic

Metabolic Health

Insulin resistance, blood sugar regulation, metabolic syndrome, and body composition

461 articles

CGM Devices for Longevity Tracking Lack Robust Evidence Despite Growing Hype

Continuous glucose monitors are popular in biohacking circles, but direct evidence linking CGM use to extended lifespan remains thin.

Review

May 3, 2026 0

Metabolic Health

How to Crush Sugar Cravings Using Brain and Gut Science

Huberman breaks down the neuroscience of sugar desire and shares practical tools to regulate blood glucose and curb cravings.

Insulin Resistance Decoded: Ectopic Lipids, Mitochondrial Failure, and the mTOR-IRS Axis

A deep mechanistic exploration of how ectopic lipid accumulation, mitochondrial dysfunction, mTOR-IRS1 feedback, and inflammatory crosstalk converge to drive age-related insulin resistance — plus emerging therapeutic strategies.

Inside the Insulin Cascade: Receptors, Signals, and Why They Fail

Go beyond the basics to explore the molecular machinery of insulin signaling — from receptor activation to GLUT4 translocation — and understand exactly how this cascade breaks down in insulin resistance and aging.

The Aging Fat Furnace: Why Brown Fat Fades and How to Reignite It

Explore how brown and beige fat activity declines with age, the metabolic ripple effects this creates, and the evidence-backed lifestyle strategies that can help restore thermogenic function.

White, Brown & Beige Fat: Your Body's Hidden Metabolic Toolkit

Discover the three types of fat tissue in your body, what makes each one unique, and why activating the right kind could be a key to healthier aging.

GLP-1 in Action: How Your Gut Hormone Orchestrates Metabolic Balance

Go beyond the basics and explore how GLP-1 coordinates insulin release, appetite suppression, and cellular protection — and why these mechanisms matter for long-term metabolic health.

Sirtuins: The NAD+-Powered Guardians of Cellular Longevity

Explore how sirtuins use NAD+ as a molecular switch to regulate aging, DNA repair, and metabolism — and what happens when this system breaks down.

TutorialIntermediate

May 2, 2026 0

Metabolic Health

Liver Support Systems Show No Clear Survival Benefit in Acute Liver Failure

A Cochrane meta-analysis of 11 RCTs finds very low-certainty evidence that liver support systems neither reduce mortality nor improve key outcomes in ALF.

Review

May 1, 2026 0

Metabolic Health

Dextrose Injections Outperform Hyaluronic Acid for Knee Osteoarthritis Pain

A 2025 mini-review synthesizes RCTs and meta-analyses showing hypertonic dextrose prolotherapy rivals or beats standard OA injections.

Research Paper

Apr 30, 2026 0

Metabolic Health

Common Pesticide Exposure Linked to Rising Diabetes Risk Over Six Years

A large prospective cohort study finds long-term exposure to pyrethroid pesticides raises fasting glucose, insulin resistance, and type 2 diabetes risk.

Research Paper

Apr 28, 2026 0

Metabolic Health

Complete 2025 Guide to Obesity Drugs From Orlistat to Triple Agonists

Mayo Clinic review covers every FDA-approved obesity medication plus pipeline drugs, with head-to-head weight loss data and clinical best practices.

Research Paper

Apr 27, 2026 0

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