Insulin resistance, blood sugar regulation, metabolic syndrome, and body composition
461 articles
A systematic review of 38 trials finds tirzepatide cuts HbA1c nearly 3x more than lixisenatide with similar GI side effect rates.
A Bayesian network meta-analysis of 19 RCTs finds retatrutide tops weight loss but dual agonists offer the best efficacy-safety balance.
New review reveals GLP-1 receptor agonists may cause significant muscle mass loss, raising sarcopenia concerns for millions of users.
A completed University of Michigan trial explored how aerobic exercise training alters RAGE-mediated inflammatory pathways in type 2 diabetic adults.
A new ESRRA-ATG5 axis links mitochondrial recycling to arginine metabolism, and a plant polyphenol activates it to protect diabetic kidneys.
Knocking out BNIP3 in macrophages reduced adipose inflammation and improved insulin sensitivity in obese mice, revealing a new therapeutic target.
A 10-year MRI follow-up of two RCTs finds visceral fat reduction — not weight loss — drives lasting cardiometabolic protection.
New evidence reveals mitochondria form functionally distinct subpopulations within tissues and even single cells, reshaping how we understand energy metabolism.
New review reveals GLP-1 receptor agonists may directly suppress chronic inflammation across multiple organ systems, far beyond their metabolic benefits.
A noninvasive 13-variable score reveals how fast your liver is aging — and accelerated liver aging raises mortality risk by up to 85%.
A comprehensive review reveals how obesity and aging converge through shared inflammatory biomarkers, accelerating disease risk in the elderly.
New review reveals how popular weight-loss medications affect bone density and fracture risk — with some surprising findings.
