Brain Health
Glymphatic System Controls Alpha-Synuclein Spread in Parkinson's Disease
New mouse study reveals how the brain's waste-clearance system modulates toxic protein buildup linked to Parkinson's disease.
Research Paper
May 13, 2026 0
Topic
Alzheimer's
Alzheimer's disease research, amyloid plaques, tau tangles, and cognitive decline
410 articles
Brain Health
Neuroinflammation Drives Perivascular Space Enlargement in Brain Small Vessel Disease
PET-MRI study of 54 cSVD patients links microglial activation to enlarged white matter perivascular spaces, not BBB leakage.
Research Paper
May 13, 2026 0
Brain Health
BACE Inhibitor Atabecestat Trial in Pre-Symptomatic Alzheimer's Risk Terminated Early
A phase 2/3 trial of the BACE inhibitor atabecestat in amyloid-positive asymptomatic adults was terminated before completion, raising questions about this drug class.
Clinical Trial
May 13, 2026 0
Brain Health
Canada's Brain Health PRO Trial Tests Online Dementia Prevention at Scale
A completed Canadian platform trial enrolls 354 at-risk adults in a multidomain online brain health program targeting dementia prevention.
Clinical Trial
May 13, 2026 0
Brain Health
Current Drugs for Friedreich Ataxia Show Little Benefit After One Year
A Cochrane meta-analysis of 8 RCTs finds most pharmacological treatments fail to improve ataxia scores, though upper limb dexterity may benefit.
Review
May 13, 2026 0
Brain Health
Diabetes Treatment May Mask Alzheimer's Biomarker Signals in Research
A new study warns that diabetes medications could confound Alzheimer's biomarker studies, distorting our understanding of the diabetes-dementia link.
Research Paper
May 13, 2026 0
Brain Health
Correction Issued for Study on Mental Health of Early-Career Dementia Researchers
A formal erratum updates a 2026 cross-sectional survey on mental health factors affecting early-career dementia researchers worldwide.
Research Paper
May 13, 2026 0
Brain Health
Faulty Ion Channel in Serotonin Neurons May Drive Early Alzheimer's Spread
A key potassium channel, KCNA4, is lost in vulnerable brainstem neurons at Braak II — potentially fueling tau pathology progression.
Research Paper
May 13, 2026 0
Brain Health
Somatic Mutations in Brain Immune Cells May Drive Alzheimer's Disease
New research links somatic DNA variants in microglia-like cells to Alzheimer's pathology, opening a novel genetic avenue for disease intervention.
Research Paper
May 13, 2026 0
Brain Health
How Kidney Disease Silently Destroys the Brain Through Six Distinct Mechanisms
A major Nature Reviews Nephrology analysis reveals uremic toxins, BBB breakdown, and glymphatic failure drive cognitive decline in CKD patients.
Research Paper
May 12, 2026 0
Brain Health
How the Brain's Waste Clearance System Fails in Alzheimer's Disease
New review reveals how glymphatic and meningeal lymphatic dysfunction drive Aβ and tau buildup, and how sleep, surgery, and genetics factor in.
Research Paper
May 12, 2026 0
Brain Health
Blocking a Brain Stress Protein Clears Alzheimer's Waste and Cuts Amyloid Buildup
Deleting or inhibiting astrocytic PERK restores the brain's glymphatic drainage system and dramatically reduces Aβ and tau pathology in AD mouse models.
Research Paper
May 12, 2026 0