Cancer Research
HER2 Cancer Therapy Gets a Rethink With Immune System at the Center
New review reveals how HER2 reshapes the tumor immune environment — and why beating it requires more than blocking the oncogene.
Research Paper
May 22, 2026 0
Topic
Cancer
Latest breakthroughs in cancer research, treatment, and prevention
643 articles
Cancer Research
Cancer Cells Hide from Antibody-Drug Conjugates by Blocking Internalization
Researchers uncover how cancer cells evade ADC therapy by suppressing drug uptake — and identify a drug target to reverse resistance.
Research Paper
May 22, 2026 0
Cancer Research
Tumor Stiffness Drives Ferroptosis Sensitivity Through Iron Recycling Autophagy
Mechanical tension in the tumor microenvironment controls iron metabolism and cell death susceptibility via a novel NCOA4-FTH1 autophagy axis.
Research Paper
May 21, 2026 0
Cancer Research
New Mechanism Found That Could Reverse Drug Resistance in Colorectal Cancer
Scientists identify how the HMBOX1-HACE1-ATG5 axis suppresses autophagy to restore 5-FU chemosensitivity in colorectal cancer.
Research Paper
May 21, 2026 0
Cancer Research
Dormant Breast Cancer Cells Slashed 80–87% by Repurposed Drugs in Phase 2 Trial
A randomized trial shows hydroxychloroquine and everolimus can dramatically reduce dormant tumor cells in breast cancer survivors, potentially preventing relapse.
Research Paper
May 21, 2026 0
Cancer Research
Metabolic Enzyme DLAT Hijacks Leucine Breakdown to Fuel Liver Cancer Growth
A pyruvate metabolism enzyme suppresses leucine catabolism to keep mTOR active in liver cancer — and blocking it shrinks tumors in vivo.
Research Paper
May 21, 2026 0
Cancer Research
Pfizer Tests Novel CD47-PD-L1 Bispecific Antibody in Advanced Solid Tumors
A first-in-human Phase 1 trial evaluates PF-07257876, a dual-checkpoint bispecific antibody targeting both CD47 and PD-L1, in hard-to-treat cancers.
Clinical Trial
May 21, 2026 0
Cancer Research
NCI Trial of Dual Immunotherapy Bintrafusp Alfa for Bladder Cancer Terminated Early
A Phase II NCI trial testing bintrafusp alfa in metastatic urothelial carcinoma was terminated after enrolling only 2 patients.
Clinical Trial
May 21, 2026 0
Cancer Research
Personalized DNA Vaccine Triggers Immune Response in Deadly Brain Cancer
A bespoke DNA vaccine tailored to individual glioblastoma tumors shows promising immunological activity in one of oncology's hardest challenges.
Research Paper
May 21, 2026 0
Cancer Research
Common Asthma Drug Target May Unlock Stalled Cancer Immunotherapy
Blocking CysLTR1 reprograms immunosuppressive neutrophils and reverses resistance to anti-PD1 checkpoint therapy in mice.
Research Paper
May 21, 2026 0
Cancer Research
Lipid Molecule 12-HETE Found to Cripple Immune Cells in Liver Cancer
A newly identified lipid mediator may explain why immune cells fail to fight MASH-driven liver cancer, opening therapeutic targets.
Research Paper
May 21, 2026 0
Cancer Research
Immune Cells May Shield Lynch Syndrome Patients From Colorectal Cancer
MAIT cells appear to provide protective immune surveillance in Lynch syndrome carriers who haven't developed colorectal cancer, suggesting new risk stratification tools.
Research Paper
May 21, 2026 0