Topic

Heart Disease

Cardiovascular health, heart failure, atherosclerosis, and cardiac research

460 articles

Obicetrapib Cuts Coronary Events 32% in High-Risk Heart Patients
Heart Health

Obicetrapib Cuts Coronary Events 32% in High-Risk Heart Patients

A pooled analysis of 2,884 patients finds obicetrapib significantly reduces coronary events after 6 months, with striking lipid improvements.

Research Paper
Jun 4, 2026 0
Oxidized Phospholipids on Lp(a) Drive Long-Term Heart Attack Risk Independent of Platelet Effects
Heart Health

Oxidized Phospholipids on Lp(a) Drive Long-Term Heart Attack Risk Independent of Platelet Effects

In 2,040 coronary angiography patients, OxPL-apoB predicted MI-free survival but showed no link to platelet reactivity, implicating Lp(a) as the key mediator.

Research Paper
Jun 4, 2026 0
Oral GLP-1 Drug Orforglipron Slashes Blood Pressure, Cholesterol and Inflammation in Phase 2 Trials
Heart Health

Oral GLP-1 Drug Orforglipron Slashes Blood Pressure, Cholesterol and Inflammation in Phase 2 Trials

A pill-form GLP-1 receptor agonist significantly reduced multiple cardiovascular risk markers in both T2D and obesity patients over 26–36 weeks.

Research Paper
Jun 4, 2026 0
17-Protein Blood Panel Predicts Heart Failure Risk in Diabetics Far Better Than Standard Tests
Heart Health

17-Protein Blood Panel Predicts Heart Failure Risk in Diabetics Far Better Than Standard Tests

A proteomics screen of 2,920 plasma proteins identifies a 17-protein score that lifts heart failure prediction accuracy to 0.833 C-index in type 2 diabetes patients.

Research Paper
Jun 3, 2026 0
CCTA vs Calcium Scoring: Which Heart Test Should Guide Prevention
Heart Health

CCTA vs Calcium Scoring: Which Heart Test Should Guide Prevention

Leading cardiologists from Brigham and Johns Hopkins debate which imaging tool better directs primary prevention decisions.

Research Paper
Jun 2, 2026 0
Bariatric Surgeon Who Lost 50 Pounds on Tirzepatide Defends Statins and GLP-1s
Heart Health

Bariatric Surgeon Who Lost 50 Pounds on Tirzepatide Defends Statins and GLP-1s

Dr. Terry Simpson brings personal experience with FH, tirzepatide, and statins to a blunt takedown of health misinformation.

Podcast
Jun 2, 2026 0
Cardiac Sarcoidosis Linked to Autoimmune Attack on Heart's Own Proteins
Heart Health

Cardiac Sarcoidosis Linked to Autoimmune Attack on Heart's Own Proteins

New molecular analysis reveals cardiac sarcoidosis triggers self-targeting antibodies against a desmosome protein, explaining its overlap with arrhythmic heart disease.

Research Paper
Jun 1, 2026 0
African Americans Carry More Unclassified FH Gene Variants That Still Raise Heart Attack Risk
Heart Health

African Americans Carry More Unclassified FH Gene Variants That Still Raise Heart Attack Risk

A large genome-first study reveals critical gaps in familial hypercholesterolemia diagnosis for people of African ancestry due to variant classification bias.

Research Paper
Jun 1, 2026 0
Tirzepatide Delivers Sweeping Cardiometabolic Benefits Beyond Weight Loss
Heart Health

Tirzepatide Delivers Sweeping Cardiometabolic Benefits Beyond Weight Loss

A comprehensive review reveals tirzepatide improves blood pressure, lipids, liver fat, kidney function, and slashes 10-year cardiovascular risk by up to 23.5%.

Research Paper
May 30, 2026 0
Enzyme CTSL Triggers Rogue Notch1 Signaling That Drives Artery-Aging and Plaque
Heart Health

Enzyme CTSL Triggers Rogue Notch1 Signaling That Drives Artery-Aging and Plaque

A novel CTSL–Notch1–CUX1 pathway drives endothelial senescence and atherosclerotic plaque buildup, revealing fresh drug targets.

Research Paper
May 30, 2026 0
Bempedoic Acid Cuts Venous Clot Risk by 42% in Statin-Intolerant Patients
Heart Health

Bempedoic Acid Cuts Venous Clot Risk by 42% in Statin-Intolerant Patients

A post hoc analysis of the CLEAR Outcomes trial finds bempedoic acid significantly reduces DVT and pulmonary embolism risk.

Research Paper
May 29, 2026 0
Climate Change and Aging Are Driving a Cardiovascular Crisis Together
Heart Health

Climate Change and Aging Are Driving a Cardiovascular Crisis Together

A new JAMA Cardiology analysis warns that rising temperatures and a growing elderly population are converging to produce an unprecedented cardiac emergency.

Research Paper
May 29, 2026 0
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