CD38 Inhibitor 78c Restores NAD+ and Cuts Inflammation in Aged Immune Cells
Blocking CD38 with compound 78c replenishes NAD+, slashes inflammatory cytokines, and reduces oxidative stress in old macrophages infected with oral pathogens.
Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1,805 articles
Blocking CD38 with compound 78c replenishes NAD+, slashes inflammatory cytokines, and reduces oxidative stress in old macrophages infected with oral pathogens.
Go beyond the basics to explore the cellular and molecular machinery driving thymic involution — and the cutting-edge strategies researchers are using to reverse it.
XPRIZE Healthspan pits 10 teams against each other to restore muscle, cognition, and immunity in older adults by 2030.
Harvard Health Publishing releases 'Pathways to Longevity,' introducing aging science, hallmarks, and emerging therapies to general readers.
A new joint venture completes a key manufacturing step for a cell therapy designed to restore α-Klotho, a protein linked to aging and disease.
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New Nature studies reveal the thymus remains a critical organ in adult health, predicting mortality, cardiovascular, and cancer outcomes.
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Leading longevity scientists gathered at the GIMM Festival to debate the field's most pressing unanswered questions and future directions.
A landmark single-cell atlas of 35 human tissues reveals 12 multicellular coordination modules—and shows how cancer systematically dismantles them.
A new study reveals how reduced ER-mitochondria contact in aging hearts disrupts lipid metabolism and blocks cellular recycling, accelerating cardiac decline.
A detailed review maps how multi-day fasting alters key hormonal axes—with real benefits and real risks for healthspan.