Biological age reversal, epigenetic clocks, senolytics, and anti-aging interventions
1,811 articles
A comprehensive review confirms that regular exercise—across all modalities—dramatically reduces chronic disease risk and extends healthspan.
Scientists identify Pannexin1 as a calcium leak channel in the ER that triggers cellular senescence and kidney scarring after acute injury.
A landmark theory proposes that tumor suppression mechanisms like cellular senescence inadvertently accelerate aging by restricting tissue renewal.
Blood stem cells lacking DNMT3A gain telomerase activity and indefinite self-renewal — revealing a non-canonical longevity mechanism in clonal aging.
New research reveals how cerebrospinal fluid transport structures at the brain–meningeal border influence neurodegeneration, immunity, and aging.
A new causal framework links immune-cell gene regulation to telomere length, facial aging, and frailty—revealing drug targets hiding in plain sight.
A landmark review reveals how skin aging and systemic biological aging drive each other — and what that means for longevity medicine.
A Princeton study finds aging dramatically alters metabolite concentrations in mice, yet surprisingly preserves the major fluxes that drive metabolism.
A comprehensive 2025 review maps exactly how regular physical activity counteracts every major biological mechanism driving aging.
New UK Biobank data shows high cardiorespiratory and muscular fitness can offset accelerated biological aging and extend healthy lifespan.
A 2025 meta-analysis of 35 RCTs (~25,000 adults 50+) quantifies how diet, exercise, sleep, and social ties each reduce aging-related decline.
University of Pittsburgh researchers weigh the science of fasting, concluding benefits are plausible but unproven—and call for rigorous human trials.
