Citrus Flavonoid Hesperidin Reduces Key Inflammation Markers in Adults

Chronic inflammation accelerates aging and increases disease risk, making effective anti-inflammatory interventions crucial for longevity. This systematic review and meta-analysis provides compelling evidence that hesperidin supplementation can meaningfully reduce inflammatory burden in adults.

Researchers analyzed 10 randomized controlled trials encompassing 532 participants to evaluate hesperidin's effects on inflammation and oxidative stress markers. Hesperidin is a citrus flavonoid particularly abundant in oranges, lemons, and grapefruits.

The results showed significant reductions in C-reactive protein (CRP), a widely-used inflammation marker, and tumor necrosis factor-alpha (TNF-α), a key inflammatory cytokine. Notably, hesperidin's benefits were most pronounced in people with existing conditions like type 2 diabetes and myocardial infarction, where it also reduced interleukin-6 levels.

These findings have important implications for healthy aging strategies. Elevated CRP and TNF-α are associated with increased risks of cardiovascular disease, diabetes, and accelerated aging. By targeting these specific inflammatory pathways, hesperidin supplementation could potentially slow age-related decline and reduce disease risk.

However, the analysis included relatively few studies with modest sample sizes, and optimal dosing protocols remain unclear. Additionally, most benefits were observed in diseased populations rather than healthy adults, suggesting hesperidin may be most valuable for those already experiencing inflammatory conditions rather than as a general preventive measure.