Siim Land Cuts His Supplement Stack to Just 6 After a Decade of Testing

Most health-conscious adults accumulate supplement cabinets full of products promising outsized benefits. After ten years of personal experimentation and research, Siim Land argues that roughly 90% of those products can be discarded in favor of a small, evidence-grounded core stack.

The video covers six key supplements. Astaxanthin, a potent carotenoid antioxidant, leads the list — valued for its ability to cross the blood-brain barrier and reduce oxidative stress. Glycine and NAC (N-acetylcysteine) follow, highlighted together for their role in glutathione synthesis, a master antioxidant that declines with age. Land also distinguishes between collagen supplementation and simply taking glycine, suggesting the amino acid alone may deliver comparable benefit more efficiently.

Omega-3 fatty acids make the cut for their well-documented anti-inflammatory effects and cardiovascular and cognitive benefits. Creatine earns its place not just for muscle performance but increasingly for brain health and cellular energy metabolism — areas of growing longevity interest. Magnesium rounds out the list, addressing a widespread dietary deficiency with implications for sleep, stress response, and metabolic function.

The broader implication for longevity is significant: supplement overload can be expensive, potentially counterproductive, and distracting from foundational lifestyle factors. Land's framework encourages ruthless prioritization based on mechanistic evidence and real-world impact rather than marketing.

This content is particularly actionable for adults already optimizing diet and exercise who want a lean, effective supplement strategy. However, individual needs vary considerably based on diet, genetics, and health status, and Land himself notes this is not medical advice. Viewers should treat this as a starting framework and consult a healthcare provider before making changes to their supplement regimen.