6,382 articles
New research links multimorbidity — especially cardiometabolic disease clusters — to measurable brain-age acceleration in dementia-free older adults.
A neoantigen peptide vaccine targeting IDH1-R132H mutation doubled median survival in grade IV astrocytoma patients vs. historical benchmarks.
A single daily polypill improved ejection fraction and cut hospitalizations 60% vs. standard care in HFrEF patients.
New research reveals how lipid droplets spark the protein aggregation at the heart of Parkinson's disease, disrupting energy metabolism.
New analysis finds delayed stomach emptying accounts for only 4–6% of appetite suppression from liraglutide, challenging a popular assumption.
An 8-week feasibility trial combines NMN, urolithin A, creatine, and exercise to target individual aging patterns.
A large NHANES cohort study finds that higher serum micronutrient levels reduce all-cause mortality partly by decelerating biological aging.
A 5-year prospective study finds that fitter adults preserve kidney function longer, even before chronic kidney disease develops.
Older adults with higher cardiorespiratory fitness had ~48% lower Alzheimer's risk over 8.7 years, with a clear VO2 threshold identified.
A Nature Aging study identifies IL-11 as a key driver of ovarian matrix stiffening with age, and shows that silencing it restores fertility in aged rodents.
Two small clinical trials show BCG vaccination alters immune activity in cerebrospinal fluid and changes amyloid-β levels in older adults.
Bacteroides fragilis produces pantothenic acid in the gut, and restoring this supply reverses metabolic syndrome in animal models.
