New CSF Biomarker Fragment Could Transform Narcolepsy Type 1 Diagnosis
A truncated orexin-A fragment outperforms full-length hypocretin-1 in distinguishing narcolepsy type 1 patients from controls.
5061 articles
A truncated orexin-A fragment outperforms full-length hypocretin-1 in distinguishing narcolepsy type 1 patients from controls.
Scientists identify CD300ld as a key mechanism by which tumor-infiltrating neutrophils silence CD8+ T cells, opening a new immunotherapy target.
A prospective cohort study shows combining ctDNA with PSA levels dramatically improves survival prediction in high-volume metastatic prostate cancer patients.
Researchers matched fMRI patterns across mouse models and 1,976 humans to find autism splits into hypo- and hyperconnectivity subtypes with distinct biology.
New fMRI research from UNC Chapel Hill uncovers distinct neurological subtypes within ASD, potentially reshaping diagnosis and treatment.
SGLT2 inhibitor dapagliflozin protects diabetic kidneys by raising ฮฒ-hydroxybutyrate and suppressing iron-driven cell death (ferroptosis).
A newly uncovered TRIM28-PARP1 axis depletes NAD+ in tumors and T cells, enabling immune evasion in clear cell renal cell carcinoma.
A new study shows targeting CD38 in melanoma restores T cell energy metabolism and overcomes resistance to immune checkpoint therapies.
Researchers reveal how mechanical confinement deforms the cell nucleus, fractures mitochondria, and ignites iron-driven cell deathโwith implications for osteoarthritis.
A comprehensive review reveals how iron homeostasis governs brain health from infancy through old age and drives Alzheimer's and Parkinson's disease.
B cell lymphoma rapidly drives young T cells into a molecular and epigenetic aged state, while truly old T cells prove strangely resistant.
New review reveals how different cancer cell death pathwaysโfrom ferroptosis to pyroptosisโdetermine whether tumors fuel or suppress immune responses.