Wild-Type Tau Restrains Mitochondrial Fusion and May Accelerate Brain Aging
New research reveals normal Tau protein limits mitochondrial efficiency — its absence boosts energy output and stress resistance.
6,382 articles
New research reveals normal Tau protein limits mitochondrial efficiency — its absence boosts energy output and stress resistance.
New research identifies plasma and CSF tau biomarkers that closely mirror tau PET scans, potentially replacing costly brain imaging.
A large study of 2,795 adults finds OSA is associated with worse memory and elevated dementia risk scores, partly explained by vascular risk factors.
A 56-trial meta-analysis pinpoints the exact exercise dose and intensity that maximizes HDL cholesterol in metabolic syndrome patients.
Graph neural networks pinpoint synergistic natural compound pairs targeting four core aging pathways simultaneously.
A short-term drug combo rejuvenates aged mesenchymal stem cells, boosting proliferation and reducing inflammatory markers in vitro.
The Dog Aging Project enrolled 976 companion dogs to collect longitudinal multi-omic data—epigenome, microbiome, metabolome—as a translational aging model.
Scientists mapped 160 canine diseases across 26,614 dogs, uncovering how conditions cluster together—and how these patterns intensify with age.
A 900-dog study maps how gut microbiome composition shifts with age, diet, and behavior — with striking parallels to human aging patterns.
A landmark Dog Aging Project study finds plasma metabolites predicting all-cause mortality in dogs mirror those in nine human cohort studies.
A 2025 review reveals how skeletal muscle communicates with the brain through myokines, metabolites, and vesicles to slow cognitive ageing.
A landmark NEJM review reveals the biological mechanisms behind radiation-induced normal tissue injury and emerging strategies to minimize harm.