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New CSF Biomarker Fragment Could Transform Narcolepsy Type 1 Diagnosis
Sleep & Recovery

New CSF Biomarker Fragment Could Transform Narcolepsy Type 1 Diagnosis

A truncated orexin-A fragment outperforms full-length hypocretin-1 in distinguishing narcolepsy type 1 patients from controls.

Research Paper
May 17, 2026 0
New Immune Checkpoint Found as Neutrophils Sabotage Cancer-Fighting T Cells
Cancer Research

New Immune Checkpoint Found as Neutrophils Sabotage Cancer-Fighting T Cells

Scientists identify CD300ld as a key mechanism by which tumor-infiltrating neutrophils silence CD8+ T cells, opening a new immunotherapy target.

Research Paper
May 17, 2026 0
Combined ctDNA and PSA Testing Predicts Survival in Metastatic Prostate Cancer
Cancer Research

Combined ctDNA and PSA Testing Predicts Survival in Metastatic Prostate Cancer

A prospective cohort study shows combining ctDNA with PSA levels dramatically improves survival prediction in high-volume metastatic prostate cancer patients.

Research Paper
May 17, 2026 0
Cross-Species Brain Scans Reveal Two Distinct Biological Subtypes of Autism
Brain Health

Cross-Species Brain Scans Reveal Two Distinct Biological Subtypes of Autism

Researchers matched fMRI patterns across mouse models and 1,976 humans to find autism splits into hypo- and hyperconnectivity subtypes with distinct biology.

Research Paper
May 17, 2026 0
fMRI Reveals Hidden Brain Subtypes Within Autism Spectrum Disorder
Brain Health

fMRI Reveals Hidden Brain Subtypes Within Autism Spectrum Disorder

New fMRI research from UNC Chapel Hill uncovers distinct neurological subtypes within ASD, potentially reshaping diagnosis and treatment.

Research Paper
May 17, 2026 0
Dapagliflozin Blocks Kidney Cell Death in Diabetes via Ketone Body Pathway
Longevity & Aging

Dapagliflozin Blocks Kidney Cell Death in Diabetes via Ketone Body Pathway

SGLT2 inhibitor dapagliflozin protects diabetic kidneys by raising ฮฒ-hydroxybutyrate and suppressing iron-driven cell death (ferroptosis).

Research Paper
May 16, 2026 0
TRIM28 Fuels Kidney Cancer Immune Escape by Draining NAD+ and Boosting PD-L1
Longevity & Aging

TRIM28 Fuels Kidney Cancer Immune Escape by Draining NAD+ and Boosting PD-L1

A newly uncovered TRIM28-PARP1 axis depletes NAD+ in tumors and T cells, enabling immune evasion in clear cell renal cell carcinoma.

Research Paper
May 16, 2026 0
Blocking CD38 Revives Exhausted T Cells and Breaks Immunotherapy Resistance
Longevity & Aging

Blocking CD38 Revives Exhausted T Cells and Breaks Immunotherapy Resistance

A new study shows targeting CD38 in melanoma restores T cell energy metabolism and overcomes resistance to immune checkpoint therapies.

Research Paper
May 16, 2026 0
Physical Compression Kills Cells via Ferroptosis Triggered by Mitochondrial Collapse
Longevity & Aging

Physical Compression Kills Cells via Ferroptosis Triggered by Mitochondrial Collapse

Researchers reveal how mechanical confinement deforms the cell nucleus, fractures mitochondria, and ignites iron-driven cell deathโ€”with implications for osteoarthritis.

Research Paper
May 16, 2026 0
How Brain Iron Shapes Development, Aging, and Neurodegeneration
Longevity & Aging

How Brain Iron Shapes Development, Aging, and Neurodegeneration

A comprehensive review reveals how iron homeostasis governs brain health from infancy through old age and drives Alzheimer's and Parkinson's disease.

Research Paper
May 16, 2026 0
Lymphoma Forces Young T Cells to Age Decades in Just Days
Longevity & Aging

Lymphoma Forces Young T Cells to Age Decades in Just Days

B cell lymphoma rapidly drives young T cells into a molecular and epigenetic aged state, while truly old T cells prove strangely resistant.

Research Paper
May 16, 2026 0
How Cancer Cells Die Shapes Immunity and Treatment Durability
Longevity & Aging

How Cancer Cells Die Shapes Immunity and Treatment Durability

New review reveals how different cancer cell death pathwaysโ€”from ferroptosis to pyroptosisโ€”determine whether tumors fuel or suppress immune responses.

Research Paper
May 16, 2026 0
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