20 articles
A completed University of Kansas trial investigates whether creatine monohydrate can support brain energy metabolism in Alzheimer's patients.
AI-driven study identifies α-amyrin from fruits and vegetables as a promising Alzheimer's treatment that protects mitochondria and reduces tau tangles.
New research reveals how TDP-43 protein causes energy failure in motor neurons, pointing to potential metabolic therapies for ALS.
Arginine supplements reduced toxic amyloid buildup, brain inflammation, and behavioral decline in fly and mouse Alzheimer's models.
A completed Phase 4 trial from India evaluates whether ALA supplementation boosts flunarizine's migraine-prevention power in adolescents.
A traditional Chinese herbal formula improves cognition and cerebrovascular health in Alzheimer's mice by activating the LKB1-AMPK-SIRT1 autophagy cascade.
A liver enzyme released during exercise may rejuvenate brain blood vessels and protect against cognitive decline and Alzheimer's pathology.
A master autophagy regulator drops with age and in AD patients — restoring it in mice clears amyloid, reduces tau, and rescues cognition.
A new oral GLP-1 receptor agonist penetrates the brain, restoring astrocyte-neuron metabolic crosstalk disrupted in Alzheimer's disease.
AAV delivery of AIBP protein restores cholesterol balance, silences inflammation, and preserves vision in glaucoma models.
New brain organoid study shows autophagy-boosting compounds can clear harmful tau proteins and rescue synapses in Alzheimer's disease models.
A Phase 2 open-label trial explores whether an approved immune drug can raise frataxin protein levels and slow neurological decline in Friedreich Ataxia.
A completed pilot trial tests whether 2g/day of a novel carnosine formulation can restore neuromuscular function and quality of life in MS patients.
Deleting or inhibiting astrocytic PERK restores the brain's glymphatic drainage system and dramatically reduces Aβ and tau pathology in AD mouse models.
Simple compound successfully treats life-threatening COQ2 deficiency in newborn, offering hope for rare mitochondrial disorders.
NGP 555 targets toxic brain protein production in healthy volunteers, offering potential early intervention for Alzheimer's prevention.
A Phase 1 trial examines how gadobutrol moves through and exits the bodies of newborns and toddlers undergoing routine contrast MRI.
A study of 991 blood metabolites finds ergothioneine has the strongest association with cognition, and antacid use may deplete it.
After ischemic stroke, a mislocated brain water channel (AQP4) disrupts waste clearance. Blocking AQP4 with TGN-020 corrects its position and restores glymphatic flow.
Emergency case study shows how brain imaging helps diagnose life-threatening metabolic crisis in alcohol-related emergency.
