20 articles
αKG supplementation restores glutamine metabolism and halts cartilage destruction in OA models through H3K27me3 demethylation.
Study reveals how the metabolite alpha-ketoglutarate prevents arterial hardening by modulating DNA methylation and inflammation.
New research reveals how α-ketoglutarate regulates AMPK synthesis, offering potential cancer therapy targets through energy stress.
A TCA cycle metabolite reprograms inflammatory macrophages after myocardial infarction, revealing a novel metabolite-epigenetic therapeutic pathway.
New research reveals how the metabolite α-ketoglutarate enhances trophectoderm formation from human embryonic stem cells.
Calcium alpha-ketoglutarate rescues memory-related synaptic plasticity in Alzheimer's mice, pointing to a geroprotective supplement as a potential AD therapy.
Scientists pinpoint the AKG-IDH1-RPS23 axis as a key regulator of stem cell senescence, opening new doors for anti-aging metabolic therapies.
Singapore researchers find calcium alpha-ketoglutarate repairs brain cell communication and restores early memory abilities in Alzheimer's models.
Thomas DeLauer reveals how glycine supports liver detoxification, boosts glutathione production, and enhances metabolic flexibility.
A study of 4,260 health enthusiasts found delayed-release calcium-AKG was associated with measurably younger epigenetic age.
Scientists discover how TCA cycle enzyme OGDH directs intestinal cell differentiation, offering new therapeutic targets for inflammatory bowel disease.
A completed trial investigates whether replenishing glutathione precursors can reverse metabolic dysfunction in elderly adults.
A new study identifies AMPKα2 as a dedicated amino acid detector that suppresses protein overproduction — with direct links to Alzheimer's disease.
Dr. Dominic D'Agostino explains how ketogenic therapies may help Alzheimer's patients by providing alternative brain fuel and reducing inflammation.
A pyruvate metabolism enzyme suppresses leucine catabolism to keep mTOR active in liver cancer — and blocking it shrinks tumors in vivo.
Researchers discover how a bacterial enzyme helps H. pylori survive stomach acid and colonize the gut, opening new therapeutic avenues.
Taurine activates OGT/Gpx4 signaling to halt ferroptosis in chondrocytes, offering a safe dietary strategy against post-traumatic osteoarthritis.
Research reveals α1-acid glycoprotein could protect against metabolic liver disease by targeting both liver and fat tissue dysfunction.
A completed University of Kansas trial investigates whether creatine monohydrate can support brain energy metabolism in Alzheimer's patients.
Glycoconjugates of carnosine and GHK paired with copper act as SOD mimics and trigger trophic factor release, pointing to new longevity therapies.
