20 articles
New research reveals how α-ketoglutarate regulates AMPK synthesis, offering potential cancer therapy targets through energy stress.
A pyruvate metabolism enzyme suppresses leucine catabolism to keep mTOR active in liver cancer — and blocking it shrinks tumors in vivo.
A newly discovered enzyme-driven feedback cycle helps liver tumors suppress immunity and resist checkpoint blockade — and blocking it may help.
A newly identified enzyme links lactate metabolism to liver cancer progression, and a natural compound delivered via nanoparticles shows striking anti-tumor results.
Ketogenic diet metabolite enhances CAR T cell metabolism and tumor control in multiple cancer models
AML stem cells produce BHB via autonomous ketogenesis to block ferroptosis, revealing a targetable metabolic vulnerability in leukemia.
Metabolite supplement protects heart from chemo toxicity and enhances tumor suppression in breakthrough dual-action study.
A phase 2 trial shows rogaratinib produces durable responses in a hard-to-treat GIST subtype driven by epigenetic oncogene activation.
A macrophage-derived metabolite rewires tumor metabolism and flips immune cells from tumor-promoting to tumor-fighting.
New research reveals how bone marrow cells produce taurine that feeds leukemia stem cells, offering potential therapeutic targets.
GLP-1 receptor agonists may overcome Lenvatinib resistance in hepatocellular carcinoma by targeting a key glycolytic vulnerability.
A comprehensive review reveals how iron-driven cell death can be exploited to treat ATC, one of the most lethal human cancers.
A growth factor called GDF11 reprograms pro-tumor macrophages by rewiring their metabolism, suppressing hepatocellular carcinoma growth.
Phase 3 trial pits next-gen GnRH antagonist degarelix against standard goserelin in prostate cancer hormone suppression.
A phase 1 trial shows Temferon — a gene-engineered stem cell therapy — safely delivers interferon-α into glioblastoma tumors with no dose-limiting toxicities.
Scientists develop brain-penetrating drug that makes glioblastoma cells vulnerable to targeted elimination therapy.
New research reveals how a metabolic enzyme fuels hepatocellular carcinoma progression through altered lipid synthesis pathways.
New research reveals how the ketogenic diet's main ketone body might enhance cancer metastasis through a novel protein modification mechanism.
A phase II trial explores whether the amino acid L-arginine, with or without enzyme inhibitors, can improve erectile function and quality of life after prostate cancer radiation therapy.
Review reveals how cardiolipin dysregulation drives glioblastoma survival and identifies potential therapeutic vulnerabilities.
