20 articles
A completed trial investigates whether replenishing glutathione precursors can reverse metabolic dysfunction in elderly adults.
A new ESRRA-ATG5 axis links mitochondrial recycling to arginine metabolism, and a plant polyphenol activates it to protect diabetic kidneys.
Dom D'Agostino returns to STEM-Talk to unpack 20+ new papers on ketogenic metabolic therapy for cancer, ketone supplement safety, and HBOT for TBI.
Master the advanced molecular architecture of AMPK — from isoform-specific signaling and spatial compartmentalization to emerging pharmacological strategies targeting the energy sensor at the heart of longevity biology.
Ketone body β-OHB prevents sepsis-induced liver damage by modifying antioxidant enzyme SOD2, offering new therapeutic approach.
Breakthrough study reveals sepiapterin dramatically outperforms existing PKU therapy, offering hope for better metabolic control.
AICAR-driven AMPK activation rescues mitochondrial energy balance in hypoxic corneal cells, pointing to a new therapy for keratopathy.
A new framework reveals how lactate and β-hydroxybutyrate team up across organs to regulate metabolism, mitochondria, and disease.
A molecular-level deep dive into AGE formation kinetics, RAGE isoforms, downstream transcriptional networks, and evidence-based interventions — for those who want the full mechanistic picture.
Go beyond the basics and explore the biochemical mechanisms behind glycation — from the Maillard reaction cascade to RAGE signaling and tissue cross-linking — to understand why AGEs are central to aging and metabolic disease.
New research identifies choline kinase alpha as a key driver of diabetic retinopathy and microvascular dysfunction.
New research reveals how glucose metabolism directly controls fat tissue expansion through a novel epigenetic pathway involving JMJD1A.
A comprehensive review finds SGLT2 inhibitors reduce AKI risk in humans via hemodynamic, metabolic, and cellular protective pathways.
A 2025 mini-review synthesizes RCTs and meta-analyses showing hypertonic dextrose prolotherapy rivals or beats standard OA injections.
A new PTM called lysine pyruvylation links glycolytic activity directly to gene regulation, with SIRT3 acting as the eraser.
A Phase IIa trial explores whether the HIF-PHI drug daprodustat can safely replace EPO injections in hemodialysis patients with anemia.
Landmark CKD trials enrolled mostly overweight patients — new evidence questions whether SGLT2 inhibitors work for lean, non-diabetic individuals.
Scientists identify how a metabolic enzyme drives kidney inflammation in diabetes, opening doors for targeted therapies.
Comprehensive review reveals hexokinase method as the most precise technique for glucose testing in clinical laboratories.
A traditional Chinese formula and its key compound GsRg1 restore brain insulin signaling in obese rats by activating hypothalamic self-cleaning pathways.
