Gut Metabolite Desaminotyrosine Prevents Transplant Complications While Fighting Cancer
Bacterial metabolite from flavonoids protects against graft-versus-host disease while preserving anti-cancer effects in stem cell transplants.
20 articles
Bacterial metabolite from flavonoids protects against graft-versus-host disease while preserving anti-cancer effects in stem cell transplants.
A novel gut microbiome metabolite chemically modifies liver proteins, impairing mitochondrial function and insulin signaling in obesity and fatty liver disease.
New research reveals how low tryptophan levels in portal blood create hyper-reactive immune cells that worsen liver damage in alcohol-related disease.
GOULASH trial compares feeding strategies for pancreatitis patients to optimize recovery outcomes.
A bacterial gut metabolite worsens Alzheimer's pathology by damaging the blood-brain barrier and promoting tau tangles.
A gut-derived compound linked to red meat consumption may accelerate bone aging by activating a key inflammatory pathway in osteoblasts.
A completed clinical trial tests whether a prebiotic blend can boost Akkermansia muciniphila and support weight management in metabolic syndrome.
Synthetic biology meets the microbiome: designer probiotics restore gut-liver-brain balance better than rifaximin in preclinical models.
New research reveals how androgen deprivation therapy disrupts gut microbiome and bile acids, causing memory problems through brain signaling pathways.
New research reveals how gut microbes produce fatty acids that hijack cellular cleanup systems, leading to fat accumulation and immune dysfunction.
Multi-omics study reveals how specific gut microbes produce acetate to protect liver function and prevent metabolic disorders in dairy cows.
Study shows probiotic bacteria shields heart muscle from toxic effects of cancer chemotherapy through metabolite pathway.
New research reveals how gut microbiota-derived succinate exacerbates allergic airway inflammation by altering lung proteins.
Fecal transplants from cancer survivors significantly improved treatment outcomes for metastatic kidney cancer patients.
New fusion model accurately predicts survival outcomes for liver cancer patients receiving TACE therapy using CT scans and biomarkers.
Study reveals how gut microbiota-derived propionic acid can restore reproductive function and reverse aging effects through gut-organ communication.
A 61-analyte, three-matrix metabolomics platform outperforms standard bile acid testing by exposing gut-liver dynamics that single-sample methods miss.
Aging reduces beneficial gut bacteria that produce NDGA, a compound that prevents inflammatory bowel disease by blocking immune cell death.
A microbial enzyme from Bifidobacterium enhances anti-TNF therapy efficacy in IBD by reshaping immune regulation via histone lactylation.
A landmark review reveals how microbiome disruption before and after stem cell transplants drives deadly graft-versus-host disease.