20 articles
αKG supplementation restores glutamine metabolism and halts cartilage destruction in OA models through H3K27me3 demethylation.
Study reveals how the metabolite alpha-ketoglutarate prevents arterial hardening by modulating DNA methylation and inflammation.
A TCA cycle metabolite reprograms inflammatory macrophages after myocardial infarction, revealing a novel metabolite-epigenetic therapeutic pathway.
New research reveals how the metabolite α-ketoglutarate enhances trophectoderm formation from human embryonic stem cells.
Calcium alpha-ketoglutarate rescues memory-related synaptic plasticity in Alzheimer's mice, pointing to a geroprotective supplement as a potential AD therapy.
Scientists pinpoint the AKG-IDH1-RPS23 axis as a key regulator of stem cell senescence, opening new doors for anti-aging metabolic therapies.
Singapore researchers find calcium alpha-ketoglutarate repairs brain cell communication and restores early memory abilities in Alzheimer's models.
A study of 4,260 health enthusiasts found delayed-release calcium-AKG was associated with measurably younger epigenetic age.
Scientists discover how TCA cycle enzyme OGDH directs intestinal cell differentiation, offering new therapeutic targets for inflammatory bowel disease.
A new study identifies AMPKα2 as a dedicated amino acid detector that suppresses protein overproduction — with direct links to Alzheimer's disease.
Dr. Dominic D'Agostino explains how ketogenic therapies may help Alzheimer's patients by providing alternative brain fuel and reducing inflammation.
Researchers discover how a bacterial enzyme helps H. pylori survive stomach acid and colonize the gut, opening new therapeutic avenues.
Taurine activates OGT/Gpx4 signaling to halt ferroptosis in chondrocytes, offering a safe dietary strategy against post-traumatic osteoarthritis.
A comprehensive review of AGIs explains how acarbose and miglitol manage type 2 diabetes while reducing hypoglycemia and lactic acidosis risks.
Study reveals ergothioneine concentrates in oxidative stress-prone tissues like slow-twitch muscle and brown fat.
Argininosuccinate lyase deficiency disrupts ammonia processing, causing brain, liver, and vascular damage across a lifetime.
AAV9 gene therapy safely delivered missing enzyme to children with GM1 gangliosidosis, stabilizing development and improving brain markers.
Glycoconjugates of carnosine and GHK paired with copper act as SOD mimics and trigger trophic factor release, pointing to new longevity therapies.
Scientists reveal how thymine DNA glycosylase removes the adenine oxidation lesion oxoA, a DNA damage implicated in cancer and aging.
Review examines urolithin A's potential as sports supplement, highlighting mitochondrial benefits and safety profile across multiple athletic applications.
