12 articles
The TCA cycle is a central metabolic hub linking energy production, amino acid synthesis, and cholesterol regulation — all critical to aging biology.
αKG supplementation restores glutamine metabolism and halts cartilage destruction in OA models through H3K27me3 demethylation.
A subpopulation of intestinal stem cells enriched for old mitochondria produces more α-ketoglutarate, driving Paneth cell regeneration and tissue niche renewal.
A TCA cycle metabolite reshapes immune responses through epigenetic and covalent mechanisms, opening doors for cancer and autoimmune therapies.
A TCA cycle metabolite reprograms inflammatory macrophages after myocardial infarction, revealing a novel metabolite-epigenetic therapeutic pathway.
A longitudinal mouse study identifies sex-specific plasma metabolite biomarkers of frailty, pointing to B vitamins in females and lipids in males.
A new viewpoint challenges the '900-day rule' in aging research, arguing that healthspan—not just lifespan—must be geroscience's primary target.
New research reveals how the metabolite α-ketoglutarate enhances trophectoderm formation from human embryonic stem cells.
Study reveals how the metabolite alpha-ketoglutarate prevents arterial hardening by modulating DNA methylation and inflammation.
Scientists discover how TCA cycle enzyme OGDH directs intestinal cell differentiation, offering new therapeutic targets for inflammatory bowel disease.
Comprehensive study reveals metabolic aging patterns across organs and identifies compounds that could slow aging processes.
Singapore researchers find calcium alpha-ketoglutarate repairs brain cell communication and restores early memory abilities in Alzheimer's models.
