20 articles
αKG supplementation restores glutamine metabolism and halts cartilage destruction in OA models through H3K27me3 demethylation.
Study reveals how the metabolite alpha-ketoglutarate prevents arterial hardening by modulating DNA methylation and inflammation.
New research reveals how α-ketoglutarate regulates AMPK synthesis, offering potential cancer therapy targets through energy stress.
A TCA cycle metabolite reprograms inflammatory macrophages after myocardial infarction, revealing a novel metabolite-epigenetic therapeutic pathway.
New research reveals how the metabolite α-ketoglutarate enhances trophectoderm formation from human embryonic stem cells.
Calcium alpha-ketoglutarate rescues memory-related synaptic plasticity in Alzheimer's mice, pointing to a geroprotective supplement as a potential AD therapy.
Scientists pinpoint the AKG-IDH1-RPS23 axis as a key regulator of stem cell senescence, opening new doors for anti-aging metabolic therapies.
A study of 4,260 health enthusiasts found delayed-release calcium-AKG was associated with measurably younger epigenetic age.
Scientists discover how TCA cycle enzyme OGDH directs intestinal cell differentiation, offering new therapeutic targets for inflammatory bowel disease.
A new study identifies AMPKα2 as a dedicated amino acid detector that suppresses protein overproduction — with direct links to Alzheimer's disease.
A pyruvate metabolism enzyme suppresses leucine catabolism to keep mTOR active in liver cancer — and blocking it shrinks tumors in vivo.
Researchers discover how a bacterial enzyme helps H. pylori survive stomach acid and colonize the gut, opening new therapeutic avenues.
Taurine activates OGT/Gpx4 signaling to halt ferroptosis in chondrocytes, offering a safe dietary strategy against post-traumatic osteoarthritis.
Research reveals α1-acid glycoprotein could protect against metabolic liver disease by targeting both liver and fat tissue dysfunction.
Glycoconjugates of carnosine and GHK paired with copper act as SOD mimics and trigger trophic factor release, pointing to new longevity therapies.
Scientists reveal how thymine DNA glycosylase removes the adenine oxidation lesion oxoA, a DNA damage implicated in cancer and aging.
Review examines urolithin A's potential as sports supplement, highlighting mitochondrial benefits and safety profile across multiple athletic applications.
A 2-week glycine supplementation trial in 19 severely obese adults reversed glycine deficiency and improved key liver and lipid markers.
Research on Candida albicans uncovers how protein interactions regulate toxic compound removal and cellular health balance.
Molecular hydrogen reduced liver damage from acetaminophen overdose in diabetic mice, outperforming standard antidote NAC on mitochondrial oxidative stress.
