20 articles
A new framework reveals how lactate and β-hydroxybutyrate team up across organs to regulate metabolism, mitochondria, and disease.
A new review identifies PRMT enzymes as master regulators linking mitochondrial stress to sarcopenia and neuromuscular decline.
A Cochrane meta-analysis of 11 RCTs finds very low-certainty evidence that liver support systems neither reduce mortality nor improve key outcomes in ALF.
A new review argues that combining GLP-1 receptor agonists with structured exercise and dietary support preserves muscle and delivers lasting fat loss.
A Cochrane meta-analysis of 8 RCTs finds most pharmacological treatments fail to improve ataxia scores, though upper limb dexterity may benefit.
A paradigm-shifting review proposes that α-synuclein pathology originates in the kidneys and spreads to the brain via PKC signaling.
A Cochrane meta-analysis of 17 RCTs finds amyloid-targeting antibodies offer minimal cognitive gains while significantly raising ARIA risk.
A new meta-analysis of 37,393 patients finds GLP-1 receptor agonists may reduce mortality and major cardiac events in type 2 diabetics with prior MI.
New review links physical activity to glymphatic function — the brain's built-in detox network that flushes neurotoxic proteins.
A new review maps how tirzepatide's dual GIP/GLP-1 action reshapes metabolism across the pancreas, liver, gut, heart, kidneys, and brain.
A systematic review of 13 studies finds semaglutide and liraglutide meaningfully cut BMI and improve blood sugar in children and adolescents.
A new review reframes magnesium as a master regulator of mitochondrial energy, metabolic disease, and biological aging.
A new review links adult cholestasis to pediatric genetic syndromes, opening doors to targeted therapies including novel bile acid transport inhibitors.
A landmark review reveals astrocytes as active immune players whose dysfunction drives Alzheimer's, Parkinson's, MS, and ALS.
A landmark review reframes astrocytes as multilayered processing units that regulate synapses, circuits, and brain function at multiple spatial scales.
A major review repositions type 2 diabetes as a proteinopathy, with amylin aggregation bridging metabolic decline and neurodegeneration.
A meta-analysis of 4,941 adults finds FTO risk-allele carriers have higher triglycerides on calorie-restricted diets, but most metabolic markers respond similarly across genotypes.
Longevity experts endorse CGMs for metabolic optimization, but RCT evidence in non-diabetics is still thin.
Biomolecular condensates formed by liquid-liquid phase separation offer a new platform for clearing disease-causing proteins conventional drugs can't target.
A landmark review argues neurodegeneration is driven by interacting misfolded proteins, not single culprits — reshaping diagnosis and treatment.
