Brain Health
Fatty Acid Molecule Erucamide Halts Retinal Degeneration in Mice
A naturally occurring fatty acid amide activates immune cells in the retina, protecting neurons and blood vessels from degenerative damage.
Research Paper
Jun 21, 2026 0
Results for "Bempedoic Acid" in Parkinson's
20 articles
Brain Health
BACE Inhibitor Atabecestat Trial in Pre-Symptomatic Alzheimer's Risk Terminated Early
A phase 2/3 trial of the BACE inhibitor atabecestat in amyloid-positive asymptomatic adults was terminated before completion, raising questions about this drug class.
Clinical Trial
May 13, 2026 0
Brain Health
Herbal Compound Clears Alzheimer's Plaques by Activating AMPK Autophagy Pathway
A traditional Chinese herbal formula improves cognition and cerebrovascular health in Alzheimer's mice by activating the LKB1-AMPK-SIRT1 autophagy cascade.
Research Paper
May 21, 2026 0
Brain Health
New Alzheimer's Drug BMS-984923 Completes Safety Testing in 51 Participants
Phase 1b trial tests escalating doses of experimental Alzheimer's treatment BMS-984923 for safety and tolerability in older adults.
Clinical Trial
Mar 28, 2026 1
Brain Health
Pramipexole Shows Promise for Treatment-Resistant Depression in Major UK Trial
Dopamine agonist pramipexole significantly reduced depression symptoms when added to standard antidepressants in resistant cases.
Research Paper
Apr 8, 2026 0
Brain Health
Alpha-Lipoic Acid Added to Flunarizine Tested for Teen Migraine Prevention
A completed Phase 4 trial from India evaluates whether ALA supplementation boosts flunarizine's migraine-prevention power in adolescents.
Clinical Trial
Jun 17, 2026 0
Brain Health
Retired Cholesterol Drug Shows Promise for Alzheimer's Prevention in Small Trial
Probucol, a discontinued cholesterol medication, may boost brain-protective proteins in older adults at risk for dementia.
Clinical Trial
Mar 29, 2026 0
Brain Health
Drugs That Boost Brain Waste Clearance During Sleep Show Promise Against Alzheimer's
A Phase 1/2 trial tests whether dexmedetomidine can enhance the brain's glymphatic system to clear amyloid and tau during sleep.
Clinical Trial
May 16, 2026 0
Brain Health
Repurposed Anti-Nausea Drug TEP Tested for Clearing Alzheimer's Brain Plaques
A Phase 2 trial investigates whether thiethylperazine, a decades-old antiemetic, can flush toxic amyloid beta from the brains of early AD patients.
Clinical Trial
Jun 12, 2026 0
Brain Health
Food Toxin Cyclopiazonic Acid Damages Memory and Learning in Mice Study
Emerging mycotoxin found in foods crosses blood-brain barrier, disrupts neurotransmitters and impairs cognitive function in animal model.
Research Paper
Apr 14, 2026 0
Brain Health
Adenosine Receptor Blocker Boosts Brain Recovery After Stroke by 40%
DPCPX treatment enhanced neurogenesis and improved motor/memory function in stroke recovery studies using advanced PET imaging.
Research Paper
Apr 9, 2026 0
Brain Health
Anti-Amyloid Alzheimer's Drugs Show Trivial Cognitive Benefit With Real Brain Bleed Risk
A Cochrane meta-analysis of 17 RCTs finds amyloid-targeting antibodies offer minimal cognitive gains while significantly raising ARIA risk.
Review
Apr 20, 2026 0
Brain Health
ML Pipeline Advances Detection of Age-Related Brain Microbleeds in Mouse Model
Researchers built a machine learning imaging pipeline to detect cerebral microhemorrhages and tested SS-31 (elamipretide) in aged hypertensive mice.
Research Paper
May 20, 2026 0
Brain Health
New Antidepressant Strategy Targets Brain Receptors for Rapid Relief
Scientists develop pathway-selective drug that activates beneficial brain receptors while avoiding negative feedback loops.
Research Paper
Apr 8, 2026 0
Brain Health
High Palmitoleic Acid Linked to 65% Greater Brain Glucose Decline in Midlife
A 5-year cohort study finds elevated blood palmitoleic acid โ a marker of excess energy intake โ accelerates brain hypometabolism linked to cognitive decline.
Research Paper
Jun 12, 2026 0
Brain Health
New Psychedelic-Like Compounds Treat Depression Without Causing Hallucinations
UC Davis scientists created novel brain-healing molecules that activate key serotonin receptors tied to neuroplasticity โ without triggering hallucinations.
Press Release
May 14, 2026 0
Brain Health
Rapastinel Shows Lower Abuse Potential Than Ketamine in Phase 1 Trial
A completed Phase 1 trial compared the abuse liability of rapastinel versus ketamine in recreational polydrug users, with implications for safer depression treatment.
Clinical Trial
Jun 5, 2026 0
Brain Health
New Compound Prevents Brain Degeneration in Frontotemporal Dementia Mouse Model
Researchers discover a phospholipid derivative that protects brain cells by calming overactive immune cells in dementia-prone mice.
Research Paper
Mar 29, 2026 1
Brain Health
Exercise Hormone Beta-Endorphin Forms Protective Shield Around Alzheimer's Plaques
ฮฒ-endorphin released during exercise wraps around toxic Aฮฒ aggregates, forming a 'corona' that shields brain cells from Alzheimer's damage.
Research Paper
May 8, 2026 0
Brain Health
Scientists Engineer Magic Mushroom Compound That Treats Depression Without Hallucinations
Researchers created modified psilocin that maintains antidepressant effects while dramatically reducing psychedelic side effects in mice.
Press Release
Mar 29, 2026 1
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