20 articles
A comprehensive review of in vitro assays for inducing cellular senescence and screening senolytic drugs, highlighting key challenges in clinical translation.
Fucoidan, dasatinib+quercetin, and MitoQ each counteract hyperoxia-driven cellular senescence in fetal airway cells via distinct mechanisms.
A new study pinpoints chemotherapy-induced senescent bone marrow cells as the culprit behind bone loss, and shows senolytics can prevent it.
A phase 1 trial of dasatinib + quercetin in 5 early AD patients uncovers fluid biomarker changes that could guide future senolytic trials.
4-month senolytic treatment with D+Q cleared senescent RPE cells, reduced lipofuscin, and preserved vision in a preclinical dry AMD model.
Dasatinib and quercetin clear senescent cochlear cells, reducing inflammation and preserving hair cells in aging mice.
Comprehensive review identifies senolytics, NAD+ precursors, mTOR inhibitors and other compounds targeting aging hallmarks.
Dasatinib and quercetin, a leading senolytic combo, unexpectedly reduced myelination in healthy mouse brains, mimicking multiple sclerosis damage.
Dasatinib plus quercetin cleared senescent cells and reduced inflammation, improving alveolar bone health in aged mice.
Review reveals how anti-cancer drugs are being repurposed to eliminate senescent cells, opening new pathways for longevity treatments.
Alendronate-modified liposomes carrying dasatinib and quercetin doubled bone volume in chemotherapy-induced osteoporosis models.
New research reveals how aging liver cells release harmful vesicles that promote cancer metastasis across multiple tumor types.
Researchers develop BH3 profiling to predict senolytic drug effectiveness, moving beyond one-size-fits-all aging treatments.
Dasatinib and quercetin nanoparticles improve egg quality and fertility in aging mouse ovaries by clearing senescent cells.
New review reveals senolytic therapies can both help and harm cardiovascular health, challenging clinical translation.
Study shows senolytic combination therapy reduces cellular aging in gums and prevents periodontal bone loss in aging mice.
New research reveals how a key protein causes mesothelial cells to age prematurely, leading to dangerous scarring in dialysis patients.
Widely-used anti-aging drug combination unexpectedly increased kidney injury markers in mice, raising safety concerns for clinical use.
Dasatinib plus quercetin cleared senescent cells and restored kidney function in diabetic mice, offering hope for human treatment.
Comprehensive review reveals how drugs that eliminate or modify senescent cells could revolutionize anti-aging medicine.
