Dietary Fat Rewires the Circadian Clock to Track the Seasons
A single phosphorylation site on clock protein PER2, triggered by dietary fat, controls how fast mice synchronize to seasonal light cycles.
20 articles
A single phosphorylation site on clock protein PER2, triggered by dietary fat, controls how fast mice synchronize to seasonal light cycles.
Following Mediterranean or MIND diets for decades significantly reduced dementia risk and slowed cognitive aging in 130,000+ adults.
A 5-year cohort study finds elevated blood palmitoleic acid — a marker of excess energy intake — accelerates brain hypometabolism linked to cognitive decline.
16-week ketogenic diet study shows sex-specific microbiome and brain metabolite changes in APOE4 mice, with greatest benefits in females.
A randomized pilot study finds PEMF therapy significantly improved fatigue, sleep, depression, and walking capacity in post-COVID-19 patients over 5 weeks.
A new study warns that diabetes medications could confound Alzheimer's biomarker studies, distorting our understanding of the diabetes-dementia link.
A 9-day intranasal insulin regimen restored working memory, recognition memory, and reduced neuroinflammation in mice engineered to mimic hippocampal aging.
A new metabolomics study links diet and exercise to blood pathway scores that track cognitive and physical decline across CN, MCI, and Alzheimer's stages.
Comprehensive review examines dietary approaches like gluten-free, ketogenic, and supplement protocols for ASD symptom management.
Stanford researchers find pioglitazone and liraglutide improve CNS insulin signaling, measured via neuron-derived vesicles in blood.
Editorial reviews emerging treatments including brain stimulation, psychedelics, and microbiome therapies for eating disorders.
Nicotinamide riboside prevents moyamoya-like brain vessel blockages by fixing cellular energy production in smooth muscle cells.
A new biomarker study shows CSF TMEM106B protein drops with worsening FTD and predicts brain shrinkage and faster decline.
A naturally occurring fatty acid amide activates immune cells in the retina, protecting neurons and blood vessels from degenerative damage.
Scientists developed mitoDREADD-Gs, a novel tool that restores cognitive function by enhancing mitochondrial activity in mouse models of dementia.
New research reveals how TDP-43 protein causes energy failure in motor neurons, pointing to potential metabolic therapies for ALS.
A Danish double-blind RCT tests a novel at-home electromagnetic field headband against sham for moderate-to-severe depression over 8 weeks.
A GeneReviews update details how activating MTOR variants cause a rare overgrowth-intellectual disability syndrome, with early rapamycin trials showing promise.
New drug FP802 disrupts toxic brain signaling, preventing memory loss and brain damage in Alzheimer's mouse models.
Case study shows how methylmalonic acidemia disrupts dopamine pathways, causing severe movement disorders in adults.