20 articles
Demethyleneberberine, derived from traditional Chinese medicine, significantly reduced lung scarring by targeting NLRP3 inflammasome and EMT in mice.
New research reveals efgartigimod reshapes B-cell populations in myasthenia gravis, inducing regulatory plasma cells linked to clinical improvement.
Natural flavonoid fisetin activates mitophagy and xenophagy pathways to restrict intracellular Salmonella growth in immune cells.
New spatial multiomics study maps cellular interactions in systemic sclerosis, revealing fibroblast-macrophage dynamics.
New review reveals how immune cells orchestrate tissue scarring across organs, offering therapeutic targets for fibrosis affecting nearly a billion people.
A new review reveals how cellular crosstalk, non-coding RNAs, and lung microbiota drive pulmonary fibrosis — and where treatments may break through.
A pilot study finds one 30-minute PAPIMI electromagnetic field session significantly reduced pain scores and raised parasympathetic HRV markers in chronic musculoskeletal pain patients.
New research reveals how tissue fibroblasts orchestrate age-related inflammation, creating exhausted T cells that increase vulnerability to disease.
A Stanford RCT finds pulsed electromagnetic field therapy significantly reduces thumb CMC osteoarthritis pain at 6 weeks, even after treatment ends.
Scientists discover tumor-associated immune cells can promote nerve growth and dramatically improve spinal cord injury recovery.
A mechanistic deep-dive into cutting-edge anti-inflammaging interventions — from senolytic pharmacology and precision cytokine targeting to partial reprogramming strategies that aim to restore youthful immune homeostasis.
Phase 1 trial examines whether vesatolimod can safely stimulate immune response in HIV controllers during treatment interruption.
Master the molecular architecture of complement dysregulation in aging — from regulatory protein biochemistry to cutting-edge therapeutic targets — and understand how precision interventions can restore balance without dismantling immunity.
Structural biology uncovers the exact amino acid motif causing species-specific drug failures, enabling transgenic mouse models for better P2X7 drug testing.
A deep mechanistic exploration of neutrophil extracellular trap biology in the context of aging — from PAD4 citrullination dynamics and gasdermin-driven release to clinical immunopathology and next-generation therapeutic targets.
Stanford researchers used modified immune proteins to enhance neurogenesis and cognitive function in aged mouse brains.
65 neurologists from 54 Italian MS centers agree on when and how to use high-efficacy therapies to prevent irreversible disability.
A phase 1/2 trial finds low-dose oral NMN safely raises platelet counts in steroid-refractory ITP via a novel immunometabolic mechanism.
A completed RCT tests whether 1-hour pathogen detection paired with antimicrobial stewardship slashes broad-spectrum antibiotic days in HAP patients.
New research identifies Lp-PLA2 enzyme as therapeutic target for deadly lung disease affecting millions of workers worldwide.
