Brain Support Protein GFAP Emerges as Key Driver of Neurodegeneration
New research reveals how GFAP protein actively shapes brain aging and could enable early detection of neurodegenerative diseases.
20 articles
New research reveals how GFAP protein actively shapes brain aging and could enable early detection of neurodegenerative diseases.
A 4-protein panel in neuronal extracellular vesicles outperforms standard plasma tests in flagging early Alzheimer's brain changes.
MethylCog, a 29-CpG blood test, indexes general cognitive ability and improves mild cognitive impairment detection beyond age and sex alone.
New research identifies specific blood markers that independently predict both physical frailty and cognitive decline.
Applied Cognition tests a wearable device that tracks glymphatic function overnight, comparing it to MRI, EEG, and blood biomarkers.
Study of 2,366 women shows biological aging markers predict future increases in tau, amyloid, and neuroinflammation proteins linked to dementia.
Dive into the molecular machinery behind lifelong brain health โ from BDNF-TrkB signaling cascades and adult hippocampal neurogenesis to glymphatic amyloid clearance and cutting-edge interventions including senolytics, GLP-1 agonists, and transcranial stimulation.
New AI model using blood tests better predicts brain aging and amyloid buildup linked to dementia risk.
A bibliometric analysis of 595 papers maps how glymphatic-Alzheimer's research has grown exponentially, pinpointing AQP4, sleep, and DTI-ALPS imaging as the hottest frontiers.
DNA methylation biomarkers from a simple blood test may track cognitive aging and neurological disease risk with unprecedented precision.
A global consortium reveals how tube type, delays, and storage temperature dramatically skew key Alzheimer's blood biomarker readings.
A 5-year cohort study finds elevated blood palmitoleic acid โ a marker of excess energy intake โ accelerates brain hypometabolism linked to cognitive decline.
New cerebrospinal fluid protein biomarker can predict which Alzheimer's patients will maintain cognitive function despite brain pathology.
New mouse study reveals aging causes region-specific neuroinflammation and perineuronal net accumulation linked to memory decline.
A new NEJM case report highlights cerebral amyloid angiopathy, a vascular brain condition closely tied to cognitive decline and stroke risk.
A spatial proteomics platform profiled 700,000+ brain cells, identifying a microglial subset that clusters around amyloid-ฮฒ plaques in Alzheimer's disease.
In CADASIL patients, MRI-derived brain age runs years ahead of chronological age, tracking disease severity and cognitive decline.
Scientists uncover the molecular mechanisms driving microglial aging in the brain, offering insights into neurodegeneration.
New review maps how ฮฑ-synuclein assays may detect Parkinson's before symptoms appear โ and what stands between lab and clinic.
New research reveals how glucose availability directs brain cell proliferation via a metabolic-epigenetic axis, with implications for MS and brain repair.