20 articles
Glycans β sugar molecules on proteins β shift with stress, diet, and lifestyle, and may predict disease a decade before symptoms appear.
A 20,000-person study finds IgG glycan patterns track biological aging, predict mortality, and shift toward youth with interventions.
GlycanAge's Dubrovnik conference targets translating 25 years of inflammaging research into real clinical tools for doctors and patients.
A 20,000-person study validates IgG glycans as aging biomarkers, with therapeutic plasma exchange reducing glycan age by 0.4 years per month.
Researchers built a quantitative model of IgG N-glycosylation that pinpoints a key enzyme declining with age across two Croatian cohorts.
A landmark library of 226 N-glycan standards with mass spec data could transform glycoproteomics and disease biomarker discovery.
A new LC-MS/MS study finds distinct N-glycan patterns in serum that distinguish Alzheimer's stages, including hard-to-detect MCI subtypes.
Scientists mapped how aging rewires protein glycosylation in the thymus, uncovering sugar patterns that drive immune decline.
Synthetic glycan microarrays reveal how human and mouse immune systems respond to Candida, pinpointing key oligosaccharide targets for diagnostics and vaccines.
The oligosaccharide H3N2b achieves 100% diagnostic accuracy in plasma and CSF and falls with AAV9 gene therapy β a breakthrough for this fatal brain disease.
A molecular-level deep dive into AGE formation kinetics, RAGE isoforms, downstream transcriptional networks, and evidence-based interventions β for those who want the full mechanistic picture.
A new review reveals how protein glycosylationβa key cellular modificationβfuels aging and diabetes, and how phytochemicals may intervene.
Glycine supplementation may slow aging by reducing AGEs, harmful molecules that damage collagen and drive chronic disease.
A multi-method bioinformatics study pinpoints MAX, MLEC, and TMEM59 as key N-glycosylation-linked diagnostic markers for early Alzheimer's detection.
Scientists discover how a sugar metabolism byproduct can halt a key aging mechanism linked to chronic inflammation.
Age-related loss of Ξ±2,6-sialic acid on T cells impairs immune responses to infection and cancer, with PD-1 blockade partially rescuing function.
Nephropathic Cystinosis alters serum N-glycosylation patterns, especially sialylation, offering potential new disease biomarkers.
Plasma N-glycan profiling distinguishes MS from AQP4-Ab NMOSD and MOGAD with up to 80.5% accuracy, offering a noninvasive diagnostic complement.
GlycanDIA workflow enables precise detection of low-abundance glycans, uncovering distinct RNA glycosylation patterns.
Newly discovered glycosylated RNAs interact with immune receptors, challenging biology dogma and opening doors to novel therapies.
