20 articles
Researchers built a quantitative model of IgG N-glycosylation that pinpoints a key enzyme declining with age across two Croatian cohorts.
A landmark library of 226 N-glycan standards with mass spec data could transform glycoproteomics and disease biomarker discovery.
A new LC-MS/MS study finds distinct N-glycan patterns in serum that distinguish Alzheimer's stages, including hard-to-detect MCI subtypes.
Scientists mapped how aging rewires protein glycosylation in the thymus, uncovering sugar patterns that drive immune decline.
Synthetic glycan microarrays reveal how human and mouse immune systems respond to Candida, pinpointing key oligosaccharide targets for diagnostics and vaccines.
The oligosaccharide H3N2b achieves 100% diagnostic accuracy in plasma and CSF and falls with AAV9 gene therapy — a breakthrough for this fatal brain disease.
A new review reveals how protein glycosylation—a key cellular modification—fuels aging and diabetes, and how phytochemicals may intervene.
A multi-method bioinformatics study pinpoints MAX, MLEC, and TMEM59 as key N-glycosylation-linked diagnostic markers for early Alzheimer's detection.
Scientists discover how a sugar metabolism byproduct can halt a key aging mechanism linked to chronic inflammation.
Age-related loss of α2,6-sialic acid on T cells impairs immune responses to infection and cancer, with PD-1 blockade partially rescuing function.
Nephropathic Cystinosis alters serum N-glycosylation patterns, especially sialylation, offering potential new disease biomarkers.
Plasma N-glycan profiling distinguishes MS from AQP4-Ab NMOSD and MOGAD with up to 80.5% accuracy, offering a noninvasive diagnostic complement.
GlycanDIA workflow enables precise detection of low-abundance glycans, uncovering distinct RNA glycosylation patterns.
Newly discovered glycosylated RNAs interact with immune receptors, challenging biology dogma and opening doors to novel therapies.
A 10,000-person genome-wide study doubles known genetic loci for blood protein sugar modifications, revealing liver disease and inflammation links.
Scientists identify blood biomarkers from aging immune cells that predict mobility, metabolism, and body composition changes in over 1,000 adults.
New research reveals how age-related changes in IgG antibodies fuel chronic inflammation and disrupt gut health, offering new therapeutic targets.
Spatial glycomics imaging reveals outer-arm fucosylated N-glycans as powerful prognostic markers in the most aggressive breast cancer subtype.
A cross-sectional study finds self-reported physical activity is not robustly associated with IgG N-glycan profiles in young adults.
Scientists developed OMICmAge, a biological age test that integrates multiple data types to predict chronic disease risk and mortality better than existing biomarkers.
