20 articles
Comprehensive review reveals how immunosenescence creates tumor-promoting environments and reduces treatment effectiveness in elderly cancer patients.
A landmark multi-omic study of 300+ adults reveals non-linear T cell reprogramming and TH2 bias in midlife that blunts vaccine responses.
A comprehensive 2025 review maps the molecular and cellular mechanisms driving immune aging, from SASP to epigenetic drift.
A landmark 2025 review maps the molecular and cellular mechanisms driving immune aging, linking inflammaging to cancer, neurodegeneration, and infection.
Immunosenescence reshapes immune function in ways that fuel autoimmune disease — and new therapies targeting aging immune cells may reverse the damage.
Researchers show that enhancing thymic epithelial cell activity in aged mice rebuilds naïve T-cell populations and dramatically improves survival after infection.
New research reveals why some aging cells evade immune detection while others don't, opening doors for targeted therapies.
A landmark review reveals why aging immune systems lose the ability to clear senescent cells — and how new therapies could restore this critical defense.
Scientists show transient reprogramming factors can rejuvenate tissues and extend lifespan while preserving cell identity.
New precision approach safely rejuvenates senescent cells using targeted gene therapy, extending lifespan in mice.
Restoring NAD+ levels in elderly patients' T cells reverses age-related dysfunction, offering a new 'Metabolic-Immunotherapy' approach for cancer treatment.
Phase 2 trial combining senescent cell-clearing drugs with anti-PD-1 therapy achieved 33% response rate in head and neck cancer patients.
New single-cell sequencing methods uncover previously unknown changes in immune cells during aging, opening doors to personalized treatments.
Clearing zombie cells then restoring stem cell activity produced far greater lifespan gains than either approach alone.
New research reveals how stem cell reprogramming can reset aging markers and extend lifespan in mouse models.
New research explores the bidirectional relationship between aging and immunity, revealing how immune changes affect both lifespan and healthspan.
New research reveals how partial cellular reprogramming consistently modulates key aging processes across species and cell types.
Review explores how thymosin alpha-1 could restore immune function by reversing thymic involution and reducing chronic inflammation in aging.
Large veteran cohort study reveals specific immune markers predict dramatic longevity benefits over 15 years.
New research reveals how cellular identity loss accelerates aging and disease, but Yamanaka factors can reverse this process.
