20 articles
A comprehensive review reveals how obesity and aging converge through shared inflammatory biomarkers, accelerating disease risk in the elderly.
A molecular-level deep dive into AGE formation kinetics, RAGE isoforms, downstream transcriptional networks, and evidence-based interventions — for those who want the full mechanistic picture.
A new review links feline age-related obesity to SASP-driven chronic inflammation, offering translational insights for human metabolic disease.
New composite biomarker combining inflammation, nutrition, and immunity markers shows promise for cardiovascular risk assessment.
Researchers analyzed 2,911 proteins in 50,506 people to create a frailty score that predicts disease risk and biological aging.
ApoB and lipoprotein A emerge as superior predictors of cardiovascular risk compared to traditional LDL cholesterol measurements.
A noninvasive 13-variable score reveals how fast your liver is aging — and accelerated liver aging raises mortality risk by up to 85%.
New research reveals how gut bacteria, toxic fats, and immune responses create parallel inflammatory attacks on the liver.
Go beyond the basics and explore the biochemical mechanisms behind glycation — from the Maillard reaction cascade to RAGE signaling and tissue cross-linking — to understand why AGEs are central to aging and metabolic disease.
New research reveals how psoriasis increases inflammatory bowel disease risk by disrupting intestinal fat metabolism through immune cells.
New research reveals how obesity triggers chronic inflammation and how GLP-1 medications provide anti-inflammatory benefits independent of weight loss.
New research reveals how adrenaline from hypoglycemia causes prolonged inflammatory responses lasting up to seven days.
A completed University of Michigan trial explored how aerobic exercise training alters RAGE-mediated inflammatory pathways in type 2 diabetic adults.
Massive study reveals protein and metabolite signatures that could detect heart, kidney, eye and nerve damage before symptoms appear.
Knocking out BNIP3 in macrophages reduced adipose inflammation and improved insulin sensitivity in obese mice, revealing a new therapeutic target.
Large-scale protein analysis enhanced diabetes risk prediction by 23-29%, offering new tools for early prevention strategies.
A systematic review of 8 studies finds tirzepatide significantly reduces hsCRP and IL-6 across all doses and populations.
Three NIH-funded studies this week tackle metabolic decline, cardiac risk, and brain tumors — all with aging implications.
Large NHANES study shows TyG-ABSI index better predicts cardiovascular disease and death in metabolic syndrome patients than standard measures.
Scientists discover how platelet-activating factor drives liver damage in obese women, revealing potential therapeutic targets.
