Inflammaging Drives Epigenetic Aging Across Four Biological Clocks
New research links chronic low-grade inflammation to faster epigenetic aging, measured across four validated biological clocks.
20 articles
New research links chronic low-grade inflammation to faster epigenetic aging, measured across four validated biological clocks.
BioAge's oral NLRP3 inhibitor BGE-102 cut hsCRP by ~85% in weeks, signaling a potential breakthrough in treating chronic inflammation at scale.
BioAge's oral drug BGE-102 dramatically reduced hsCRP and IL-6 in obese participants with elevated inflammation, with a strong safety profile.
GlycanAge's Dubrovnik conference targets translating 25 years of inflammaging research into real clinical tools for doctors and patients.
New research reveals how single meals with certain foods can trigger dangerous inflammatory spikes in just hours.
BioAge's oral drug BGE-102 cut a key cardiovascular risk biomarker by up to 86% in obese patients, rivaling higher doses at just 60mg daily.
Scientists discover R-loops in senescent cells trigger inflammatory secretions, linking a transcription glitch to a key aging mechanism.
Glycans โ sugar molecules on proteins โ shift with stress, diet, and lifestyle, and may predict disease a decade before symptoms appear.
New research reveals how fat-derived molecules naturally shut down inflammation, offering hope for safer arthritis and heart disease treatments.
BioAge's BGE-102 enters Phase 2 with dramatic Phase 1 CRP reductions, targeting cardiovascular risk through inflammasome blockade.
A 20,000-person study finds IgG glycan patterns track biological aging, predict mortality, and shift toward youth with interventions.
Scientists boosted a protein that dampens chronic inflammation, and older mice grew stronger, more energetic, and had healthier bones.
New research reveals which foods actually reduce inflammatory markers like IL-6, with surprising results about whole foods vs supplements.
Belgian biotech Coultreon raises $125M to advance an oral SIK3 inhibitor that rebalances inflammation rather than suppressing immunity outright.
A 20,000-person study validates IgG glycans as aging biomarkers, with therapeutic plasma exchange reducing glycan age by 0.4 years per month.
A class of modified amino acids found in dog blood may unlock new ways to measure and track biological aging across species.
Scripps Research identifies a molecular switch called SNO-STING that locks brain immune cells in overdrive, damaging nerve connections in Alzheimer's.
A Japanese study of 495 centenarians finds elevated NfL blood levels strongly linked to worse cognition and 36% higher mortality risk.
A simple ultrasound test predicted cardiovascular events far better than SCORE2 in rheumatic disease patients, offering a new screening tool.
A daily tomato-soy juice rich in lycopene and isoflavones significantly reduced inflammatory proteins in adults with obesity after just four weeks.