Inflammaging May Be a Western Phenomenon, Not a Universal Aging Hallmark
A major cross-population study finds that chronic inflammation linked to aging may reflect industrialized lifestyles, not biology alone.
20 articles
A major cross-population study finds that chronic inflammation linked to aging may reflect industrialized lifestyles, not biology alone.
Analysis of nearly 2,000 adults reveals systemic immune-inflammation index strongly correlates with epigenetic age acceleration.
New research reveals how chronic inflammation varies by person, paving the way for personalized interventions to combat age-related diseases.
Higher fibrinogen and immune activation scores in middle age strongly predicted who would develop frailty decades later.
Mendelian randomization links circulating inflammatory proteins to retinal microvascular changes, heart disease risk, and lifespan — establishing causal direction.
A comprehensive review reveals how obesity and aging converge through shared inflammatory biomarkers, accelerating disease risk in the elderly.
A comprehensive review reveals how inflammaging—the fusion of aging and inflammation—fuels cardiovascular disease through senescence, mitochondrial dysfunction, and gut dysbiosis.
New research reveals how low-grade inflammation creates a cycle of liver damage in older adults, pointing to promising therapeutic targets.
Study of 470 older adults reveals strong connection between periodontal inflammation and systemic inflammatory markers.
Higher TNF-α levels at baseline increased injury risk by 25% per unit, while IL-1RA showed protective effects in runners.
A simple ratio of platelets, neutrophils, and lymphocytes emerges as a versatile inflammation biomarker across major autoimmune diseases.
Revolutionary framework combines quarterly biomarker testing with AI-powered lifestyle coaching to reduce aging-related inflammation.
Research from sub-Saharan Africa shows urbanization dramatically alters inflammaging patterns, challenging universal aging models.
New research reveals how tissue fibroblasts orchestrate age-related inflammation, creating exhausted T cells that increase vulnerability to disease.
Chinese study of 4,157 adults finds cumulative CTI index outperforms single measurements for cardiovascular risk prediction.
A comprehensive 2025 review maps the molecular and cellular mechanisms driving immune aging, from SASP to epigenetic drift.
Scientists identify blood biomarkers from aging immune cells that predict mobility, metabolism, and body composition changes in over 1,000 adults.
A 452-person study maps how inflammaging biomarkers diverge by sex across age groups, revealing the biological roots of the sex-frailty paradox.
New research reveals kidneys actively fuel systemic inflammation during aging, offering targets for longevity interventions.
New research reveals how immune aging creates systemic inflammation that accelerates kidney disease, autoimmune conditions, and other age-related illnesses.