How Aging T Cells Drive Chronic Skin Inflammation and What Can Stop Them
Senescent T cells fuel psoriasis, eczema, and rosacea through toxic secretions. New therapies may finally break the cycle.
20 articles
Senescent T cells fuel psoriasis, eczema, and rosacea through toxic secretions. New therapies may finally break the cycle.
Age-related shifts in intestinal T cell populations may silently erode gut barrier function, accelerating the chronic inflammation that drives aging diseases.
A new Cell Metabolism review from NIH identifies how ECM stiffening, poor blood flow, and mitochondrial failure lock tissues into accelerating decline.
New research reveals how people over 100 maintain youthful immune systems despite chronic inflammation, offering insights for healthy aging.
A landmark review reveals how sustained glucocorticoid exposure drives aging biology โ and what can be done about it.
A new review maps the bidirectional crosstalk between gut microbiota and cellular senescence driving multi-organ degeneration.
A new framework redefines age-related insulin resistance as a systemic collapse of metabolic resilience spanning muscle, fat, brain, and more.
A new framework proposes organ-specific biological clocks using multi-omics data to better predict disease onset and aging trajectories.
Aging disrupts gut microbiota and mTOR signaling, crippling vaccine responses โ but targeted interventions may reverse this.
Specific mutational signatures accumulate linearly with age in normal tissues, offering a new window into why cancer risk rises exponentially as we get older.
New review reveals how senescent cells both prevent and promote cancer, opening therapeutic opportunities.
An expert panel maps the pathways linking urban greenspace to Alzheimer's risk and offers researchers a standardized measurement playbook.
A landmark review maps the structural, genetic, and molecular changes that erode lung function with age โ and why reversing them matters.
A landmark review argues neurodegeneration is driven by interacting misfolded proteins, not single culprits โ reshaping diagnosis and treatment.
Virtual patient replicas built from multimodal data may slash trial costs, generate synthetic control arms, and predict treatment response in IBD.
A Cochrane meta-analysis of 17 RCTs finds amyloid-targeting antibodies offer minimal cognitive gains while significantly raising ARIA risk.
A new review reframes magnesium as a master regulator of mitochondrial energy, metabolic disease, and biological aging.
Researchers outline innovative approaches to speed up drug development for age-related diseases and longevity interventions.
Continuous glucose monitors are popular in biohacking circles, but direct evidence linking CGM use to extended lifespan remains thin.
A landmark review reveals how diet, gut bacteria, and their metabolites determine the success of immune checkpoint blockade cancer therapy.