NIH Scientists Reveal the Self-Reinforcing Loop Driving Tissue Aging
A new Cell Metabolism review from NIH identifies how ECM stiffening, poor blood flow, and mitochondrial failure lock tissues into accelerating decline.
20 articles
A new Cell Metabolism review from NIH identifies how ECM stiffening, poor blood flow, and mitochondrial failure lock tissues into accelerating decline.
Burke and Noakes reach surprising common ground on fueling endurance sport, while key disagreements remain unresolved.
A landmark review maps the structural, genetic, and molecular changes that erode lung function with age โ and why reversing them matters.
A new framework redefines age-related insulin resistance as a systemic collapse of metabolic resilience spanning muscle, fat, brain, and more.
Top longevity doctors endorse CGMs for healthy adults, but evidence is mixed. Here's what the 2026 device reviews reveal.
A Cochrane review of two RCTs finds very low-certainty evidence that IGF-1 neither prevents nor worsens retinopathy of prematurity in extremely preterm infants.
A Cochrane meta-analysis of 11 RCTs finds very low-certainty evidence that liver support systems neither reduce mortality nor improve key outcomes in ALF.
Expert reviews compare top CGMs for longevity use, but evidence for healthy adults remains limited. Here's what you need to know.
Longevity experts endorse CGMs for metabolic optimization, but RCT evidence in non-diabetics is still thin.
A new review reframes magnesium as a master regulator of mitochondrial energy, metabolic disease, and biological aging.
A 2026 Cochrane update finds most evidence on turning frequency and position for pressure injury prevention remains very low certainty.
Continuous glucose monitors are popular in biohacking circles, but direct evidence linking CGM use to extended lifespan remains thin.
Longevity experts endorse short CGM trials for non-diabetics, but RCT evidence remains thin. Here's what the data actually shows.
A Cochrane review finds only one small RCT on surgical timing for cardiac surgery, with afternoon starts linked to lower troponin release.
A landmark AHA statement challenges decades of blanket activity restrictions for children with cardiomyopathy, offering new risk-stratified guidance.
A landmark review reveals how sustained glucocorticoid exposure drives aging biology โ and what can be done about it.
A new framework proposes organ-specific biological clocks using multi-omics data to better predict disease onset and aging trajectories.
A head-to-head review of 10 CGM devices for healthy adults, weighing real-world accuracy data against limited longevity evidence.
A translational review outlines how stem cell technologies may finally make hepatocyte-based liver therapies clinically viable.
Expert reviews of top CGM platforms reveal genuine metabolic insights โ but no proof they extend lifespan in healthy adults.