Results for "Metformin TAME Trial"

20 articles

GLP-1 Drugs and Metformin Trim BMI in Obese Youth but Long-Term Safety Remains Unknown
Metabolic Health

GLP-1 Drugs and Metformin Trim BMI in Obese Youth but Long-Term Safety Remains Unknown

A Cochrane review of 37 RCTs finds obesity drugs modestly reduce weight in adolescents, but evidence quality is low and long-term data are absent.

Review
May 14, 2026 0
Expert-Backed CGMs for Healthy Adults Reveal Glucose Insights With Evidence Gaps
Metabolic Health

Expert-Backed CGMs for Healthy Adults Reveal Glucose Insights With Evidence Gaps

Longevity experts endorse short CGM trials for non-diabetics, but RCT evidence remains thin. Here's what the data actually shows.

Review
Apr 22, 2026 0
CGMs for Healthy Adults Get Expert Backing but Evidence Gaps Remain
Metabolic Health

CGMs for Healthy Adults Get Expert Backing but Evidence Gaps Remain

Longevity experts endorse CGMs for metabolic optimization, but RCT evidence in non-diabetics is still thin.

Review
Apr 20, 2026 0
Telepharmacy Cuts Blood Pressure and Boosts Medication Adherence in Chronic Disease Patients
Heart Health

Telepharmacy Cuts Blood Pressure and Boosts Medication Adherence in Chronic Disease Patients

A Cochrane review of 21 RCTs finds remote pharmacist care may improve adherence and lower blood pressure in NCD patients.

Review
Jun 13, 2026 0
AHA Sets New Standards for Measuring Heart Risk in Cancer Drug Trials
Heart Health

AHA Sets New Standards for Measuring Heart Risk in Cancer Drug Trials

A landmark AHA scientific statement tackles inconsistent cardiovascular safety reporting in oncology trials with a unified framework.

Review
Jun 16, 2026 0
Liver Support Systems Show No Clear Survival Benefit in Acute Liver Failure
Metabolic Health

Liver Support Systems Show No Clear Survival Benefit in Acute Liver Failure

A Cochrane meta-analysis of 11 RCTs finds very low-certainty evidence that liver support systems neither reduce mortality nor improve key outcomes in ALF.

Review
May 1, 2026 0
Anti-Amyloid Alzheimer's Drugs Show Trivial Cognitive Benefit With Real Brain Bleed Risk
Brain Health

Anti-Amyloid Alzheimer's Drugs Show Trivial Cognitive Benefit With Real Brain Bleed Risk

A Cochrane meta-analysis of 17 RCTs finds amyloid-targeting antibodies offer minimal cognitive gains while significantly raising ARIA risk.

Review
Apr 20, 2026 0
CGM Devices for Longevity Tracking Lack Robust Evidence Despite Growing Hype
Metabolic Health

CGM Devices for Longevity Tracking Lack Robust Evidence Despite Growing Hype

Continuous glucose monitors are popular in biohacking circles, but direct evidence linking CGM use to extended lifespan remains thin.

Review
May 3, 2026 0
CGM Devices for Biohackers Ranked by Evidence in 2026
Metabolic Health

CGM Devices for Biohackers Ranked by Evidence in 2026

A head-to-head review of 10 CGM devices for healthy adults, weighing real-world accuracy data against limited longevity evidence.

Review
May 13, 2026 0
CGMs for Longevity Seekers: Real Benefits, Real Limits and What the Evidence Actually Shows
Metabolic Health

CGMs for Longevity Seekers: Real Benefits, Real Limits and What the Evidence Actually Shows

Expert reviews of top CGM platforms reveal genuine metabolic insights โ€” but no proof they extend lifespan in healthy adults.

Review
May 12, 2026 0
CGM Devices for Biohackers Ranked: What the Evidence Actually Shows
Metabolic Health

CGM Devices for Biohackers Ranked: What the Evidence Actually Shows

Expert reviews compare top CGMs for longevity use, but evidence for healthy adults remains limited. Here's what you need to know.

Review
Apr 23, 2026 0
CGMs for Longevity Biohacking: What the Experts Actually Recommend
Metabolic Health

CGMs for Longevity Biohacking: What the Experts Actually Recommend

Top longevity doctors endorse CGMs for healthy adults, but evidence is mixed. Here's what the 2026 device reviews reveal.

Review
Apr 19, 2026 0
IGF-1 for Premature Infant Eye Disease Shows No Clear Benefit in Small Trials
Brain Health

IGF-1 for Premature Infant Eye Disease Shows No Clear Benefit in Small Trials

A Cochrane review of two RCTs finds very low-certainty evidence that IGF-1 neither prevents nor worsens retinopathy of prematurity in extremely preterm infants.

Review
Apr 20, 2026 0
CGM Devices for Longevity Biohacking Reviewed: What the Evidence Actually Shows
Metabolic Health

CGM Devices for Longevity Biohacking Reviewed: What the Evidence Actually Shows

Six leading CGM platforms compared on accuracy, evidence quality, and longevity claims โ€” most fall short of the hype.

Review
May 8, 2026 0
CGMs for Longevity Biohacking: What the 2026 Expert Reviews Actually Show
Metabolic Health

CGMs for Longevity Biohacking: What the 2026 Expert Reviews Actually Show

Dexcom G7 tops expert picks for metabolic biohacking, but evidence for non-diabetics remains mixed. Here's what the data says.

Review
Apr 26, 2026 0
Current Drugs for Friedreich Ataxia Show Little Benefit After One Year
Brain Health

Current Drugs for Friedreich Ataxia Show Little Benefit After One Year

A Cochrane meta-analysis of 8 RCTs finds most pharmacological treatments fail to improve ataxia scores, though upper limb dexterity may benefit.

Review
May 13, 2026 0
Harvard Team Outlines Rigorous Framework for Evaluating Heart Devices With Real-World Data
Heart Health

Harvard Team Outlines Rigorous Framework for Evaluating Heart Devices With Real-World Data

A Circulation review from Harvard proposes the 'target trial framework' to improve how observational data is used to assess cardiovascular device safety and effectiveness.

Review
May 19, 2026 0
How Your Gut Microbiome Controls Whether Cancer Immunotherapy Works
Gut & Microbiome

How Your Gut Microbiome Controls Whether Cancer Immunotherapy Works

A landmark review reveals how diet, gut bacteria, and their metabolites determine the success of immune checkpoint blockade cancer therapy.

Review
May 26, 2026 0
Magnesium Controls Cellular Energy and May Slow the Pace of Aging
Metabolic Health

Magnesium Controls Cellular Energy and May Slow the Pace of Aging

A new review reframes magnesium as a master regulator of mitochondrial energy, metabolic disease, and biological aging.

Review
Jun 6, 2026 0
Blue Light Surgery Cuts Bladder Cancer Recurrence by Up to 32% in High-Risk Patients
Cancer Research

Blue Light Surgery Cuts Bladder Cancer Recurrence by Up to 32% in High-Risk Patients

A Cochrane meta-analysis of 17 RCTs finds blue light TURBT reduces bladder cancer recurrence and progression, especially in intermediate- and high-risk patients.

Review
Jun 13, 2026 0
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