20 articles
A Lancet systematic review finds interactive, personalized dementia prevention programs outperform mass media campaigns in changing real-world behavior.
A computational review reveals how neural timescales link brain structure, dynamics, and cognition — with implications for brain health.
A landmark Nature Immunology review reveals adaptive immune cells actively shape neurodegeneration — and could be targeted therapeutically.
A new minireview reveals early vascular aging, endothelial dysfunction, and insulin resistance may drive MS pathogenesis before disability sets in.
A new review links BPA exposure from common plastic products to key Alzheimer's mechanisms including amyloid buildup, tau pathology, and cognitive decline.
A landmark review argues neurodegeneration is driven by interacting misfolded proteins, not single culprits — reshaping diagnosis and treatment.
A new framework warns that AI tools used too early in medical education may prevent trainees from developing core clinical reasoning skills.
A landmark review reframes astrocytes as multilayered processing units that regulate synapses, circuits, and brain function at multiple spatial scales.
A paradigm-shifting review proposes that α-synuclein pathology originates in the kidneys and spreads to the brain via PKC signaling.
A 30-study review finds exercise and mindfulness alter resting brain connectivity, but the largest rigorous trial shows minimal effects.
GLP-1 receptor agonists show early promise for co-occurring substance use and mood disorders by targeting shared brain reward pathways.
A landmark review reveals astrocytes as active immune players whose dysfunction drives Alzheimer's, Parkinson's, MS, and ALS.
New review links physical activity to glymphatic function — the brain's built-in detox network that flushes neurotoxic proteins.
A Cochrane review of two RCTs finds very low-certainty evidence that IGF-1 neither prevents nor worsens retinopathy of prematurity in extremely preterm infants.
A Cochrane meta-analysis of 8 RCTs finds most pharmacological treatments fail to improve ataxia scores, though upper limb dexterity may benefit.
A narrative review reveals India's unique dementia risk profile — and why Western findings may not apply to 1.4 billion people.
A Cochrane meta-analysis of 17 RCTs finds amyloid-targeting antibodies offer minimal cognitive gains while significantly raising ARIA risk.
A major Lancet review argues that optimizing current depression treatments may be more impactful than developing new ones.
An expert panel maps the pathways linking urban greenspace to Alzheimer's risk and offers researchers a standardized measurement playbook.
A Lancet review reveals stroke pathways fail to adequately address frailty, disability, and comorbidity — gaps with major consequences for older patients.
