20 articles
A mechanistic deep-dive into cutting-edge anti-inflammaging interventions — from senolytic pharmacology and precision cytokine targeting to partial reprogramming strategies that aim to restore youthful immune homeostasis.
Study reveals how gut microbes transform T cells into potent autoimmune drivers that migrate to joints and promote arthritis.
New research reveals how our body clock regulates immune cell function through DNA modifications, offering insights for health optimization.
New research reveals how lactate triggers lactylation, an epigenetic modification that fuels rheumatoid arthritis and lupus progression.
New research reveals how a single antibody treatment creates lasting protection against autoimmune diabetes by reshaping immune cells.
Pyruvate, a core metabolic molecule, suppresses interferon signaling by directly modifying STAT1 — linking metabolism to immune control.
Senescent cells drive cyst growth in ADPKD, and targeting them with senolytics or the aldose reductase inhibitor epalrestat delays disease progression.
Mice lacking the PERP apoptosis gene develop faulty thymic immune screening, accumulating self-reactive T-cells that trigger arthritis as they age.
Structural biology uncovers the exact amino acid motif causing species-specific drug failures, enabling transgenic mouse models for better P2X7 drug testing.
Go beyond inflammaging basics to understand how aging reshapes immune cell populations, triggers the SASP, and locks the body into a state of chronic low-grade inflammation at the molecular level.
Researchers discover LEF1 marks true self-renewing T cells in autoimmunity and chronic infection, opening new therapeutic targets.
Revolutionary precision immunotherapies use AI and cellular engineering to target lupus at its source, offering hope for durable remission.
Breakthrough treatments targeting specific immune pathways show promise for reducing steroid dependence in EGPA patients.
Researchers modified NK and T cells with special receptors that help them track down and infiltrate solid tumors more effectively.
Massive genetic analysis of 25 populations uncovers immune system variations that could explain differences in infection susceptibility.
A major review in Nature Medicine explores how CAR cell therapies may achieve deep immune 'reset' in autoimmune diseases by depleting pathogenic B cells.
Comprehensive review explores how combining genomics, proteomics, and metabolomics advances psoriasis understanding and treatment.
New research reveals efgartigimod reshapes B-cell populations in myasthenia gravis, inducing regulatory plasma cells linked to clinical improvement.
Stanford researchers used modified immune proteins to enhance neurogenesis and cognitive function in aged mouse brains.
A murine arthritis study finds rapamycin suppresses neuropeptide Y, linking cellular senescence to joint inflammation via SASP cytokines.
