Nuclear Enzyme Breakthrough Reprograms Cancer Cells to Stop Growing
Scientists discover how to reprogram cancer cells into harmless, non-dividing cells by targeting a nuclear enzyme pathway.
20 articles
Scientists discover how to reprogram cancer cells into harmless, non-dividing cells by targeting a nuclear enzyme pathway.
Dive deep into the molecular machinery of genomic instability — from telomere-driven crisis states and epigenetic remodeling at break sites to cutting-edge therapeutic strategies targeting DNA repair fidelity in aging and cancer.
MIT researchers identify oncofetal cell states in colorectal tumors that mimic embryonic intestines and prime cancer cells for invasion.
New research reveals that whole-genome doubling triggers epigenetic changes that silence antigen presentation, letting tumors evade CD8+ T cells.
Scientists discover two new histone modifications that create a self-reinforcing cycle promoting breast cancer progression.
A new review reveals how epithelial-to-mesenchymal transition fuels tumor invasion, immune evasion, and drug resistance through dynamic, reversible states.
Synthetic super-enhancers hijack glioblastoma's own regulatory circuits to trigger precise, tumor-only cell death and durable immune memory.
New research reveals how chemical tags on RNA molecules drive cancer progression and could unlock targeted treatments.
Cancer cells that downregulate SMC4 enter a low-proliferation, diapause-like state that resists standard chemotherapy, revealing a dangerous survival mechanism.
New research reveals how progenitor cells drive the transition from benign to malignant cancer, offering potential intervention targets.
New research reveals how nasopharyngeal cancer cells rewire their metabolism to survive chemotherapy, pointing to potential treatment strategies.
New technique uses cerebrospinal fluid to decode methylation signatures in children's brain tumors, potentially improving diagnosis.
Targeting a single protein in immune cells rewires cholesterol metabolism to flip immunosuppressive macrophages into tumor-fighting ones.
Researchers identify N4BP2, the enzyme behind chromothripsis - a genetic catastrophe that helps one in four cancers rapidly evolve and resist treatment.
Spatial multi-omics reveals how specific fibroblasts create immunosuppressive environments that fuel colorectal cancer spread to the liver.
A landmark Cell study reveals cells transfer cytoplasmic DNA fragments to neighbors via nanotubes, stably reshaping recipient genomes.
Researchers discover how SIRT6 protein overcomes temozolomide resistance in deadly brain cancer by modifying histone lactylation patterns.
New study reveals how cancer cells reprogram bone immune cells to fuel metastasis, offering potential therapeutic targets.
Researchers develop selective method to restore function of mutated p53 protein, potentially offering new cancer treatment strategy.
Researchers discovered how to restore tumor-killing power in worn-out immune cells by switching off just two genes.