20 articles
Breakthrough study shows one epigenetic factor can transform cardiac fibroblasts into heart muscle cells, improving function after myocardial infarction.
Novel liposome therapy delivers miR-10a to atherosclerotic plaques, reprogramming inflammatory macrophages and reducing disease progression in mice.
Cas13-based RNA editing shows promise for treating hereditary hypertrophic cardiomyopathy by correcting disease-causing mutations at the RNA level.
Revolutionary gene-editing technology CRISPR becomes available outside the US, offering new hope for treating genetic diseases worldwide.
New research shows preeclampsia disrupts cardiovascular development in both mothers and babies, creating lasting disease risk.
Researchers discover how cancer cells use metabolic enzyme PHGDH to evade immune detection, opening new combination therapy approaches.
CRISPR gene therapy shows promise for curing genetic heart diseases like high cholesterol and amyloidosis with one-time treatments.
In obese middle-aged mice, reducing dietary protein—without cutting calories—reversed cardiac inflammation and remodeling via AMPK-ULK1 mitophagy.
Deleting CPT1a in mouse livers dramatically lowers ApoB-containing lipoproteins by accelerating clearance, revealing a new lipid metabolism target.
A new nanoparticle system delivers rapamycin and a DNA scavenger directly to arterial plaques, cutting inflammation and improving plaque stability in mice.
Revolutionary approach moves beyond traditional risk assessment to target specific biological mechanisms driving heart disease.
A forward genetic screen in mice reveals HELZ2 helicase degrades APOB mRNA, linking RNA stability to fatty liver disease and heart disease risk.
A completed registry study identified and genotyped HoFH patients with LDLR mutations, laying groundwork for targeted gene therapy.
Scientists discover how an unusual gene fusion in melanoma still drives cancer growth and responds to targeted treatment.
Scientists discover how to enhance cancer immunotherapy by converting tumor-supporting immune cells into tumor-fighting ones.
Dr. Jamnadas explains how to transform dinner into a nutrient-dense feast that optimizes metabolism and feeds your microbiome.
A pilot trial explores whether intentionally inducing brief daily dyssynchrony via pacemaker can retrain failing heart muscle in humans.
A sirtuin enzyme prevents heart scarring by keeping cardiac fibroblasts from switching to a pro-fibrotic metabolic state.
New genetic approach could revolutionize how we develop heart medications, potentially saving billions in failed drug trials.
Scientists identify specific brain wave patterns that mark the transition from consciousness to unconsciousness during surgery.
