Epigenetic Reprogramming Shapes Early Mammalian Development
New review explores how epigenetic changes control the earliest stages of mammalian embryo development and cellular identity.
20 articles
New review explores how epigenetic changes control the earliest stages of mammalian embryo development and cellular identity.
New research reveals how partial cellular reprogramming consistently modulates key aging processes across species and cell types.
New research reveals how a regulatory protein prevents harmful epigenetic changes during embryo development.
Comprehensive review reveals how epigenetic drift drives aging and outlines promising rejuvenation strategies including CRISPR editing and reprogramming.
Scientists show transient reprogramming factors can rejuvenate tissues and extend lifespan while preserving cell identity.
New research reveals how stem cell reprogramming can reset aging markers and extend lifespan in mouse models.
New research reveals why stem cells from Alzheimer's patients retain disease signatures that affect brain development.
Biotech startup NewLimit is screening transcription factors to reverse cellular aging via partial reprogramming and mRNA delivery.
New research reveals how cellular identity loss accelerates aging and disease, but Yamanaka factors can reverse this process.
New small-molecule approach offers safer alternative to genetic reprogramming for turning back the cellular clock.
A lysosome-to-epigenome pathway in C. elegans extends lifespan across multiple generations via histone H3.3 transport from gut to germline.
Researchers discover that viscoelastic substrates enhance cellular plasticity by altering chromatin structure and improving reprogramming efficiency.
New precision approach safely rejuvenates senescent cells using targeted gene therapy, extending lifespan in mice.
New research explores how epigenetic modifications control the aging process and potential therapeutic targets.
Researchers develop biophysical framework connecting thermodynamic parameters to epigenetic age and entropy changes during cellular aging and rejuvenation.
Revolutionary approach using Yamanaka factors shows promise for restoring youthful function to aging retinal cells and treating blindness.
Scientists discover KLF7 can replace KLF4 in creating pluripotent stem cells, offering new pathways for regenerative medicine.
A rigorous mechanistic deep-dive into how transposable element reactivation drives aging at the molecular level — from chromatin topology disruption to therapeutic intervention strategies.
A landmark 2025 review maps how gut bacteria alter DNA methylation, histone marks, and RNA modifications to drive IBD and colorectal cancer.
Retro Biosciences used GPT-4b micro to engineer proteins that reverse cellular aging far more powerfully than evolution ever managed.