20 articles
A rigorous mechanistic deep-dive into the molecular logic of partial reprogramming — from chromatin dynamics and epigenetic clock reversal to in vivo delivery strategies, oncogenic risks, and the path to clinical translation.
Go beyond the basics and explore the precise molecular mechanisms by which Yamanaka factors remodel the epigenome, silence cell identity, and unlock pluripotency — with implications for partial reprogramming therapies.
Chinese researchers decode how chemical cocktails alone can convert adult human cells into pluripotent stem cells, bypassing gene editing.
A new review traces how aging science evolved from single-cause theories to partial reprogramming with Yamanaka factors as a lifespan-extending strategy.
Researchers erased imprinting marks in mouse sperm using dCas9-TET1, then traced how methylation partially recovered — fingering H3K9me3 as the key mediator.
Activating three Yamanaka factors — OCT4, SOX2, and KLF4 — appears to reverse epigenetic aging in human eye cells, marking a milestone in rejuvenation medicine.
A new mitochondrial epigenetic editor silences aging-linked genes without altering DNA sequence, opening doors to programmable longevity interventions.
A landmark Cell study reveals p53 actively enables chemical reprogramming to pluripotency, overturning assumptions and boosting regenerative medicine safety.
Breakthrough technology allows precise activation of genes in living animals using electromagnetic fields, opening new therapeutic possibilities.
Dive deep into partial reprogramming, niche remodeling, senolytics, and cutting-edge clinical therapies — the molecular toolkit for reversing stem cell aging.
Epicrispr's GEMS platform silences disease genes epigenetically — reversibly and safely — with a single viral vector, targeting FSHD and beyond.
New research uncovers how MECP2 protein regulates DNA damage repair in brain cells, offering insights into neurological health.
Breakthrough chemical reprogramming method transforms ordinary blood cells into versatile stem cells without genetic modification.
Researchers silenced nearly every expressed gene in human iPSCs, creating a landmark map of pluripotency's genetic architecture.
Researchers used AI protein design to rebuild prime editor enzymes, achieving up to 2.9-fold better genome editing in mice.
Master the cutting-edge molecular targets, clinical trial data, and emerging therapeutic strategies aimed at reversing ECM aging — from senolytic combinations to biomaterial scaffolds and epigenetic reprogramming.
Scientists harness natural bacterial mutation systems to engineer proteins at unprecedented speed, opening doors for drug and therapy development.
Scientists achieve first precise genome editing of human embryos, drawing both acclaim and ethical concern from the scientific community.
Harvard's CellCartographer uses machine learning to identify optimal transcription factor combinations for rapid, high-efficiency cell reprogramming.
Researchers propose using partial reprogramming to rejuvenate donor organs outside the body before transplantation.
