20 articles
A new review traces how aging science evolved from single-cause theories to partial reprogramming with Yamanaka factors as a lifespan-extending strategy.
A new review reveals how epithelial-to-mesenchymal transition fuels tumor invasion, immune evasion, and drug resistance through dynamic, reversible states.
A landmark review maps the three pillars of modern lineage tracing and how they're reshaping our understanding of cell fate decisions.
A new review identifies PRMT enzymes as master regulators linking mitochondrial stress to sarcopenia and neuromuscular decline.
A major Cell Metabolism review reveals how microbiome metabolites reprogram immune cells to drive or prevent cardiometabolic disease.
A new review reframes how myeloid cells fuel or fight tumors, pointing to plasticity — not just cell diversity — as the core therapeutic target.
Bacteriophages transferred during FMT may drive horizontal gene transfer, altering microbial function and antibiotic resistance in ways science has largely ignored.
A new review reveals how senescent healthy cells within tumors quietly drive cancer progression and therapy resistance.
Biomolecular condensates formed by liquid-liquid phase separation offer a new platform for clearing disease-causing proteins conventional drugs can't target.
A new framework reveals how lactate and β-hydroxybutyrate team up across organs to regulate metabolism, mitochondria, and disease.
New computational advances help identify which tumor peptides trigger immune responses, potentially revolutionizing personalized cancer therapy.
A major review proposes that cellular metabolism acts as a master gatekeeper of cell death, with implications for cancer, aging, and chronic disease.
A major review in Nature Medicine explores how CAR cell therapies may achieve deep immune 'reset' in autoimmune diseases by depleting pathogenic B cells.
A new review maps how blood stem cell metabolism shifts with aging and how leukemia hijacks those changes — pointing to targeted therapeutic strategies.
A new framework proposes organ-specific biological clocks using multi-omics data to better predict disease onset and aging trajectories.
A new review identifies five critical methodological pitfalls undermining microbiome-aging studies and offers a practical checklist to fix them.
A new review maps the bidirectional crosstalk between gut microbiota and cellular senescence driving multi-organ degeneration.
A new perspective in Nature Cancer outlines how genetically engineered bacteria can target and destroy tumors from within.
Machine learning and whole-genome sequencing may finally give doctors the tools to predict bacterial resistance before treatment fails.
A new review links adult cholestasis to pediatric genetic syndromes, opening doors to targeted therapies including novel bile acid transport inhibitors.
