20 articles
A multi-biomarker study finds pwMS show accelerated thymic involution, senescent T cell expansion, and neuroinflammation linked to aging.
A mechanistic deep-dive into cutting-edge anti-inflammaging interventions — from senolytic pharmacology and precision cytokine targeting to partial reprogramming strategies that aim to restore youthful immune homeostasis.
New research reveals how RNA-binding proteins orchestrate immune responses, offering insights into preventing chronic inflammation.
Mice lacking the PERP apoptosis gene develop faulty thymic immune screening, accumulating self-reactive T-cells that trigger arthritis as they age.
Go beyond inflammaging basics to understand how aging reshapes immune cell populations, triggers the SASP, and locks the body into a state of chronic low-grade inflammation at the molecular level.
Master the molecular architecture of complement dysregulation in aging — from regulatory protein biochemistry to cutting-edge therapeutic targets — and understand how precision interventions can restore balance without dismantling immunity.
Stanford researchers used modified immune proteins to enhance neurogenesis and cognitive function in aged mouse brains.
Senescent T cells fuel psoriasis, eczema, and rosacea through toxic secretions. New therapies may finally break the cycle.
Go beyond the basics to explore how complement pathways, regulatory failures, and senescent cells interact to drive the chronic inflammation that accelerates aging at the molecular level.
Discover how persistent low-grade inflammation drives the aging process and learn strategies to combat this silent threat to longevity.
New research reveals how IL-2 signaling generates special B cells that produce anti-inflammatory compounds, potentially slowing aging processes.
New research reveals how tissue fibroblasts orchestrate age-related inflammation, creating exhausted T cells that increase vulnerability to disease.
New research reveals how our body clock regulates immune cell function through DNA modifications, offering insights for health optimization.
A murine arthritis study finds rapamycin suppresses neuropeptide Y, linking cellular senescence to joint inflammation via SASP cytokines.
New research reveals B cells in brain membranes play crucial roles in neural protection, aging, and neurodegenerative diseases.
GZMK+CD8+ T cells promote chronic inflammation and aging-related disease—a newly recognized immune threat beyond cytotoxicity.
Senescent cells drive cyst growth in ADPKD, and targeting them with senolytics or the aldose reductase inhibitor epalrestat delays disease progression.
Discover how a hidden arm of your immune system called the complement system quietly drives the chronic inflammation linked to aging — and what you can do about it.
Scientists reveal how macrophages use mitochondria to clear dead cells while controlling immune responses, offering insights for healthier aging.
RA patients with interstitial lung disease show accelerated cellular aging markers — shorter telomeres and fewer mitochondrial DNA copies than RA patients without lung involvement.
