20 articles
Scientists developed aging predictors using proteins and metabolites from blood, urine, and muscle to identify accelerated aging patterns.
New aging clocks using blood proteins can identify people at higher dementia risk in midlife and late-life.
Scientists analyzed 516 tissue samples to reveal how proteins change with age, identifying key aging signatures and a critical inflection point at age 50.
New proteomic aging clocks reveal how different organs age at different rates and predict cognitive decline risk.
New proteomic clocks track aging in 10 organ systems, predicting mortality and disease risk with unprecedented accuracy across diverse populations.
A landmark Cell study builds layered biological age clocks from 2,019 people, pinpointing coagulation proteins as unexpected aging drivers.
Researchers built 11 proteome-based biological age clocks from 2,448 plasma proteins across 43,000+ participants, revealing how organ-spanning data improves longevity predictions.
A new NMR-based metabolomic aging clock achieves 0.92 correlation with chronological age and reveals disease-specific metabolic aging acceleration.
A landmark mouse proteome atlas across 32 tissues reveals how the circadian clock controls protein expression in space and time.
UK Biobank study of 44,435 people reveals genetic variants in BRCA1, POLR2A, and TET2 that accelerate biological aging measured through blood proteins.
New aging clocks use molecular markers to predict disease risk and healthspan more accurately than calendar age alone.
Study of 2,366 women shows epigenetic aging markers can forecast brain pathology progression decades before symptoms appear.
A new framework proposes organ-specific biological clocks using multi-omics data to better predict disease onset and aging trajectories.
UK Biobank analysis of 2,920 proteins in 48,728 people identifies 71 key aging biomarkers and potential drug targets.
A massive multi-species transcriptomic study reveals conserved molecular hallmarks of aging and mortality, uncovering modular architecture linking inflammation, mitochondria, and chromatin.
Revolutionary precision tools show aging varies dramatically between cell types, opening doors to targeted anti-aging interventions.
Study of 2,366 women shows biological aging markers predict future increases in tau, amyloid, and neuroinflammation proteins linked to dementia.
The circadian CLOCK protein plays a dual role in cellular senescence — supporting healthy aging in normal cells while enabling tumor growth when hijacked.
Researchers identify metabolites that accumulate in lysosomes with age, creating a molecular clock that mirrors disease patterns.
UC Berkeley researchers expose critical incoherence in DNA methylation age clocks, showing up to 54% of their features contradict actual biological trends.
